4-[1-(4-Amino-benzylcarbamoyl)-3,3-diethyl-4-oxo-azetidin-2-yloxy]-benzoic acid

Base Information

Chemical Name:4-[1-(4-Amino-benzylcarbamoyl)-3,3-diethyl-4-oxo-azetidin-2-yloxy]-benzoic acid
CAS No.:143818-91-1
Molecular Formula:C₂₂H₂₅N₃O₅
Molecular Weight:411.458
Hs Code.:

Synonyms:4-[1-(4-Amino-benzylcarbamoyl)-3,3-diethyl-4-oxo-azetidin-2-yloxy]-benzoic acid

Suppliers and Price of 4-[1-(4-Amino-benzylcarbamoyl)-3,3-diethyl-4-oxo-azetidin-2-yloxy]-benzoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[1-(4-Amino-benzylcarbamoyl)-3,3-diethyl-4-oxo-azetidin-2-yloxy]-benzoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-[1-(4-Amino-benzylcarbamoyl)-3,3-diethyl-4-oxo-azetidin-2-yloxy]-benzoic acid

There total 10 articles about 4-[1-(4-Amino-benzylcarbamoyl)-3,3-diethyl-4-oxo-azetidin-2-yloxy]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143818-90-0
4-[3,3-Diethyl-1-(4-nitro-benzylcarbamoyl)-4-oxo-azetidin-2-yloxy]-benzoic acid

: 143818-91-1
4-[1-(4-Amino-benzylcarbamoyl)-3,3-diethyl-4-oxo-azetidin-2-yloxy]-benzoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00099a003

Reference yield:

: 97-96-1
2-Ethylbutyraldehyde

: 143818-91-1
4-[1-(4-Amino-benzylcarbamoyl)-3,3-diethyl-4-oxo-azetidin-2-yloxy]-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 55 percent / sodium acetate / 48 h / Heating

2: 36 percent / CH₂Cl₂ / Ambient temperature

3: 85 percent / acetone / 0.5 h

4: triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 24 h

5: trifluoroacetic acid, anisole / 1 h / 0 °C

6: H₂ / 10 percent Pd/C / ethanol

With dmap; hydrogen; sodium acetate; methoxybenzene; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; acetone;
DOI:10.1021/jm00099a003

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 143818-91-1
4-[1-(4-Amino-benzylcarbamoyl)-3,3-diethyl-4-oxo-azetidin-2-yloxy]-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl chloride, dimethylformamide / CH₂Cl₂ / 0.42 h

2: NaN₃ / acetone; H₂O / 0.5 h / 0 - 5 °C

3: CHCl₃ / 0.5 h / Heating

4: triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 24 h

5: trifluoroacetic acid, anisole / 1 h / 0 °C

6: H₂ / 10 percent Pd/C / ethanol

With dmap; sodium azide; oxalyl dichloride; hydrogen; methoxybenzene; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; chloroform; water; acetone;
DOI:10.1021/jm00099a003