Bis-Propargyl-PEG13

Base Information

• Chemical Name: Bis-Propargyl-PEG13
• CAS No.: 1351373-50-6
• Molecular Formula: C₃₀H₅₄O₁₃
• Molecular Weight: 622.751
• Mol file: 1351373-50-6.mol

Synonyms:C₃₀H₅₄O₁₃

Chemical Property of Bis-Propargyl-PEG13

Chemical Property:

• Solubility.: Soluble in Water, DMSO, DMF, DCM

Purity/Quality:

99.3% ^*data from raw suppliers

Bis-propargyl-PEG13 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Bis-propargyl-PEG13 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Technology Process of Bis-Propargyl-PEG13

There total 1 articles about Bis-Propargyl-PEG13 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

tetraethylene glycol di(p-toluenesulfonate) (37860-51-8) + 3,6,9,12-tetraoxapentadec-14-yn-1-ol (87450-10-0) → C30H54O13 (1351373-50-6)

Guidance literature:

3,6,9,12-tetraoxapentadec-14-yn-1-ol; With sodium hydride; In tetrahydrofuran; mineral oil; for 1h;

tetraethylene glycol di(p-toluenesulfonate); In tetrahydrofuran; mineral oil; at 20 ℃; for 30h;

DOI:10.5012/bkcs.2011.32.11.3933

Reference yield: 98.0%

1-azido-3,5-dimethoxybenzene (85862-68-6) + C30H54O13 (1351373-50-6) → C48H76N6O17

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; at 50 ℃; for 1.5h;

DOI:10.5012/bkcs.2011.32.11.3933

Reference yield: 97.0%

C25H27N3O6 + C30H54O13 (1351373-50-6) → C80H108N6O25

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; at 50 ℃; for 2h;

DOI:10.5012/bkcs.2011.32.11.3933

upstream raw materials:

tetraethylene glycol di(p-toluenesulfonate)

3,6,9,12-tetraoxapentadec-14-yn-1-ol

Refernces