(+/-)-methyl 5-(4-fluorophenyl)-δ-hydroxy-3-(1-methylethyl)-β-oxo-1-phenyl-1H-pyrazole-4-heptanoate

Base Information

Chemical Name:(+/-)-methyl 5-(4-fluorophenyl)-δ-hydroxy-3-(1-methylethyl)-β-oxo-1-phenyl-1H-pyrazole-4-heptanoate
CAS No.:116645-15-9
Molecular Formula:C₂₆H₂₉FN₂O₄
Molecular Weight:452.526
Hs Code.:

Synonyms:(+/-)-methyl 5-(4-fluorophenyl)-δ-hydroxy-3-(1-methylethyl)-β-oxo-1-phenyl-1H-pyrazole-4-heptanoate

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Chemical Property of (+/-)-methyl 5-(4-fluorophenyl)-δ-hydroxy-3-(1-methylethyl)-β-oxo-1-phenyl-1H-pyrazole-4-heptanoate

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Technology Process of (+/-)-methyl 5-(4-fluorophenyl)-δ-hydroxy-3-(1-methylethyl)-β-oxo-1-phenyl-1H-pyrazole-4-heptanoate

There total 6 articles about (+/-)-methyl 5-(4-fluorophenyl)-δ-hydroxy-3-(1-methylethyl)-β-oxo-1-phenyl-1H-pyrazole-4-heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hexane-washed sodium hydride: hexane-washed sodium hydride

: 116645-14-8
5-(4-fluorophenyl)-3-(1-methylethyl)-1-phenyl-1H-pyrazole-4-propanal

: 105-45-3
acetoacetic acid methyl ester

: 116645-15-9
(+/-)-methyl 5-(4-fluorophenyl)-δ-hydroxy-3-(1-methylethyl)-β-oxo-1-phenyl-1H-pyrazole-4-heptanoate

Guidance literature:: With hydrogenchloride; n-butyllithium; In tetrahydrofuran; diethyl ether; water; acetic acid;

Reference yield:

: 114433-94-2
1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione

: 116645-15-9
(+/-)-methyl 5-(4-fluorophenyl)-δ-hydroxy-3-(1-methylethyl)-β-oxo-1-phenyl-1H-pyrazole-4-heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH, 2.) NaI / 1.) DMF, 2.) 80 to 90 deg C, 36 h

2: 40 percent / ethanol / 120 h / Heating

3: 65 percent / 70percent aq. acetic acid / 48 h / Heating

With sodium hydride; acetic acid; sodium iodide; In ethanol;
DOI:10.1021/jm00163a006

Reference yield:

: 116645-13-7
2-<2-(1,3-dioxolan-2-yl)ethyl>-1-(4-fluorophenyl)-4-methyl-1,3-pentanedione

: 116645-15-9
(+/-)-methyl 5-(4-fluorophenyl)-δ-hydroxy-3-(1-methylethyl)-β-oxo-1-phenyl-1H-pyrazole-4-heptanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / ethanol / 120 h / Heating

2: 65 percent / 70percent aq. acetic acid / 48 h / Heating

With acetic acid; In ethanol;
DOI:10.1021/jm00163a006