N-cyclopropyl-4-(2-(2-fluorophenoxy)-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)-2-methylbenzamide

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Chemical Name:N-cyclopropyl-4-(2-(2-fluorophenoxy)-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)-2-methylbenzamide
CAS No.:1610676-59-9
Molecular Formula:C₂₈H₂₉FN₆O₃
Molecular Weight:516.575
Hs Code.:

Synonyms:N-cyclopropyl-4-(2-(2-fluorophenoxy)-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)-2-methylbenzamide

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Chemical Property of N-cyclopropyl-4-(2-(2-fluorophenoxy)-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)-2-methylbenzamide

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Technology Process of N-cyclopropyl-4-(2-(2-fluorophenoxy)-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)-2-methylbenzamide

There total 6 articles about N-cyclopropyl-4-(2-(2-fluorophenoxy)-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 367-12-4
2-fluorophenol

: 1610680-36-8
N-cyclopropyl-2-methyl-4-(2-(methylsulfonyl)-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide

: 1610676-59-9
N-cyclopropyl-4-(2-(2-fluorophenoxy)-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)-2-methylbenzamide

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,2-dimethoxyethane; at 80 - 100 ℃;
DOI:10.1016/j.bmcl.2016.06.021

Reference yield:

: 1610679-35-0
8-bromo-2-(methylthio)-N-((tetrahydro-2H-pyran-4-yl)methyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine

: 1610676-59-9
N-cyclopropyl-4-(2-(2-fluorophenoxy)-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / water; tetrahydrofuran / 4 h / 130 °C / Microwave irradiation; Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 30 h / 60 °C

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 2 h / 0 - 20 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,2-dimethoxyethane / 80 - 100 °C

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2016.06.021

Reference yield:

: 345965-99-3
4-bromo-N-cyclopropyl-2-methylbenzamide

: 1610676-59-9
N-cyclopropyl-4-(2-(2-fluorophenoxy)-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium acetate / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

1.2: 4 h / 100 °C / Inert atmosphere

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / water; tetrahydrofuran / 4 h / 130 °C / Microwave irradiation; Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 30 h / 60 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 2 h / 0 - 20 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,2-dimethoxyethane / 80 - 100 °C

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2016.06.021