C₁₆H₁₈O₃

Base Information

Chemical Name:C₁₆H₁₈O₃
CAS No.:1627205-08-6
Molecular Formula:C₁₆H₁₈O₃
Molecular Weight:258.317
Hs Code.:

C<sub>16</sub>H<sub>18</sub>O<sub>3</sub>

Synonyms:C₁₆H₁₈O₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₆H₁₈O₃

Chemical Property:

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Technology Process of C₁₆H₁₈O₃

There total 5 articles about C₁₆H₁₈O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 54441-66-6
tert-butyl benzoylacetate

: 106-96-7
propargyl bromide

: 1627205-08-6
C₁₆H₁₈O₃

Guidance literature:: tert-butyl benzoylacetate; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

propargyl bromide; In tetrahydrofuran; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jacs.9b12116

Reference yield: 70.0%

: 1627205-08-6
C₁₆H₁₈O₃

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 1627205-08-6
C₁₆H₁₈O₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C / Inert atmosphere

2.1: manganese(IV) oxide / dichloromethane / 3 h / Reflux

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With manganese(IV) oxide; n-butyllithium; sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; mineral oil;
DOI:10.1002/anie.201402470