tert-butyl {(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}carbamate

Base Information

• Chemical Name: tert-butyl {(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}carbamate
• CAS No.: 1072091-15-6
• Molecular Formula: C₂₁H₃₀INO₃
• Molecular Weight: 471.379
• Mol file: 1072091-15-6.mol

Synonyms:tert-butyl {(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}carbamate

Chemical Property of tert-butyl {(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl {(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}carbamate

There total 6 articles about tert-butyl {(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

iodoform (75-47-8) + C20H29NO4 (1072091-16-7) → tert-butyl {(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}carbamate (1072091-15-6)

Guidance literature:

With chromium dichloride; In tetrahydrofuran; at 0 - 20 ℃; for 5.5h;

Reference yield:

(2R,3S,4E)-6-(benzyloxy)-3-[(4-methoxyphenyl)amino]-2,4-dimethylhex-4-en-1-ol (1072091-12-3) → tert-butyl {(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}carbamate (1072091-15-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid; periodic acid / water; acetonitrile / 1.5 h / 20 °C

1.2: 8 h / 20 °C

2.1: Dess-Martin periodane / dichloromethane / 0.17 h / 20 °C

3.1: chromium dichloride / tetrahydrofuran / 5.5 h / 0 - 20 °C

With chromium dichloride; sulfuric acid; Dess-Martin periodane; periodic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

N-[(1S,2E)-4-(benzyloxy)-1-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-2-methylbut-2-en-1-yl]-4-methoxyaniline (1072091-09-8) → tert-butyl {(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}carbamate (1072091-15-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2.1: sulfuric acid; periodic acid / water; acetonitrile / 1.5 h / 20 °C

2.2: 8 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 0.17 h / 20 °C

4.1: chromium dichloride / tetrahydrofuran / 5.5 h / 0 - 20 °C

With chromium dichloride; sulfuric acid; tetrabutyl ammonium fluoride; Dess-Martin periodane; periodic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;

upstream raw materials:

iodoform

C₂₀H₂₉NO₄

tert-butyl {(1S,2E)-4-(benzyloxy)-1-[(1R)-2-hydroxy-1-methylethyl]-2-methylbut-2-en-1-yl}carbamate

(2R,3S,4E)-6-(benzyloxy)-3-[(4-methoxyphenyl)amino]-2,4-dimethylhex-4-en-1-ol

Downstream raw materials:

C₂HF₃O₂*C₁₆H₂₂INO

C₁₆H₂₂INO

N-{(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}-7-hydroxyheptaneamide

C₁₇H₂₄INO