3-benzo[b]thiophen-2-yl-4-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-pyrrole-2,5-dione

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Chemical Name:3-benzo[b]thiophen-2-yl-4-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-pyrrole-2,5-dione
CAS No.:626605-21-8
Molecular Formula:C₃₈H₃₅N₃O₃SSi
Molecular Weight:641.866
Hs Code.:

3-benzo[<i>b</i>]thiophen-2-yl-4-{1-[3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-propyl]-1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridin-3-yl}-pyrrole-2,5-dione

Synonyms:3-benzo[b]thiophen-2-yl-4-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-pyrrole-2,5-dione

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Chemical Property of 3-benzo[b]thiophen-2-yl-4-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-pyrrole-2,5-dione

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Technology Process of 3-benzo[b]thiophen-2-yl-4-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-pyrrole-2,5-dione

There total 5 articles about 3-benzo[b]thiophen-2-yl-4-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 626605-09-2
3-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-4-chloro-pyrrole-2,5-dione

: 98437-23-1
benzo[b]thiophene-2-boronic acid

: 626605-21-8
3-benzo[b]thiophen-2-yl-4-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-pyrrole-2,5-dione

Guidance literature:: With potassium fluoride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; at 23 ℃; for 18h;
DOI:10.1016/j.bmc.2004.04.010

Reference yield:

: 626605-07-0
2-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-acetamide

: 626605-21-8
3-benzo[b]thiophen-2-yl-4-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / potassium tert-butoxide / tetrahydrofuran / 0.33 h

2: 73 percent / oxalyl chloride / CH₂Cl₂; dimethylformamide / 1 h / 23 °C

3: potassium fluoride / Pd₂(dba)3; Pd(P(t-Bu)3)2 / tetrahydrofuran / 18 h / 23 °C

With potassium fluoride; oxalyl dichloride; potassium tert-butylate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: Suzuki cross-coupling;
DOI:10.1016/j.bmc.2004.04.010

Reference yield:

: 626605-08-1
3-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-4-hydroxy-pyrrole-2,5-dione

: 626605-21-8
3-benzo[b]thiophen-2-yl-4-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / oxalyl chloride / CH₂Cl₂; dimethylformamide / 1 h / 23 °C

2: potassium fluoride / Pd₂(dba)3; Pd(P(t-Bu)3)2 / tetrahydrofuran / 18 h / 23 °C

With potassium fluoride; oxalyl dichloride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: Suzuki cross-coupling;
DOI:10.1016/j.bmc.2004.04.010