4-((5-chloro-6-isopropoxypyridin-3-yl)methoxy)-2,5-difluorobenzoic acid

Base Information

Chemical Name:4-((5-chloro-6-isopropoxypyridin-3-yl)methoxy)-2,5-difluorobenzoic acid
CAS No.:1355488-90-2
Molecular Formula:C₁₆H₁₄ClF₂NO₄
Molecular Weight:357.741
Hs Code.:

Synonyms:4-((5-chloro-6-isopropoxypyridin-3-yl)methoxy)-2,5-difluorobenzoic acid

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Chemical Property of 4-((5-chloro-6-isopropoxypyridin-3-yl)methoxy)-2,5-difluorobenzoic acid

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Technology Process of 4-((5-chloro-6-isopropoxypyridin-3-yl)methoxy)-2,5-difluorobenzoic acid

There total 4 articles about 4-((5-chloro-6-isopropoxypyridin-3-yl)methoxy)-2,5-difluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1355488-89-9
4-((5,6-dichloropyridin-3-yl)methoxy)-2,5-difluorobenzoic acid

: 67-63-0,8013-70-5
isopropyl alcohol

: 1355488-90-2
4-((5-chloro-6-isopropoxypyridin-3-yl)methoxy)-2,5-difluorobenzoic acid

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 - 90 ℃; for 18h;

Reference yield:

: 1355488-86-6
tert-butyl 4-((5,6-dichloropyridin-3-yl)methoxy)-2,5-difluorobenzoate

: 1355488-90-2
4-((5-chloro-6-isopropoxypyridin-3-yl)methoxy)-2,5-difluorobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 0.5 h

2: sodium hydride / tetrahydrofuran; mineral oil / 18 h / 80 °C / Inert atmosphere

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; mineral oil;

Reference yield:

: 446-17-3
2,4,5-trifluorobenzoic acid

: 1355488-90-2
4-((5-chloro-6-isopropoxypyridin-3-yl)methoxy)-2,5-difluorobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; di-tert-butyl dicarbonate / 16 h / 30 °C / Inert atmosphere

2: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 0.5 h

4: sodium hydride / tetrahydrofuran; mineral oil / 18 h / 80 °C / Inert atmosphere

With dmap; di-tert-butyl dicarbonate; sodium hydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; mineral oil;