4-[(5-chloro-6-isopropoxypyridin-3-yl)methoxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide

Base Information

Chemical Name:4-[(5-chloro-6-isopropoxypyridin-3-yl)methoxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide
CAS No.:1443431-08-0
Molecular Formula:C₁₈H₂₀ClF₂N₃O₅S
Molecular Weight:463.89
Hs Code.:

Synonyms:4-[(5-chloro-6-isopropoxypyridin-3-yl)methoxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide

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Chemical Property of 4-[(5-chloro-6-isopropoxypyridin-3-yl)methoxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide

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Technology Process of 4-[(5-chloro-6-isopropoxypyridin-3-yl)methoxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide

There total 5 articles about 4-[(5-chloro-6-isopropoxypyridin-3-yl)methoxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3984-14-3
N,N-dimethylsulfamide

: 1355488-90-2
4-((5-chloro-6-isopropoxypyridin-3-yl)methoxy)-2,5-difluorobenzoic acid

: 1443431-08-0
4-[(5-chloro-6-isopropoxypyridin-3-yl)methoxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide

Guidance literature:: 4-((5-chloro-6-isopropoxypyridin-3-yl)methoxy)-2,5-difluorobenzoic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.166667h;

N,N-dimethylsulfamide; at 20 ℃; for 18h;

Reference yield:

: 446-17-3
2,4,5-trifluorobenzoic acid

: 1443431-08-0
4-[(5-chloro-6-isopropoxypyridin-3-yl)methoxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap / tert-butyl alcohol / 16 h / 30 °C / Inert atmosphere

2.1: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 18 h / 20 - 90 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h

5.2: 18 h / 20 °C

With dmap; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 1355488-89-9
4-((5,6-dichloropyridin-3-yl)methoxy)-2,5-difluorobenzoic acid

: 1443431-08-0
4-[(5-chloro-6-isopropoxypyridin-3-yl)methoxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 18 h / 20 - 90 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h

2.2: 18 h / 20 °C

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;