2-{2-[4-(toluene-4-sulfonylamino)phenyl]quinazolin-4-ylamino}propionic acid

Base Information

Chemical Name:2-{2-[4-(toluene-4-sulfonylamino)phenyl]quinazolin-4-ylamino}propionic acid
CAS No.:940352-23-8
Molecular Formula:C₂₄H₂₂N₄O₄S
Molecular Weight:462.529
Hs Code.:

Synonyms:2-{2-[4-(toluene-4-sulfonylamino)phenyl]quinazolin-4-ylamino}propionic acid

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Chemical Property of 2-{2-[4-(toluene-4-sulfonylamino)phenyl]quinazolin-4-ylamino}propionic acid

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Technology Process of 2-{2-[4-(toluene-4-sulfonylamino)phenyl]quinazolin-4-ylamino}propionic acid

There total 4 articles about 2-{2-[4-(toluene-4-sulfonylamino)phenyl]quinazolin-4-ylamino}propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 940352-11-4
N-[4-(4-chloroquinazolin-2-yl)phenyl]-4-methylbenzenesulfonamide

: 302-72-7,25191-17-7,18875-37-1
rac-Ala-OH

: 940352-23-8
2-{2-[4-(toluene-4-sulfonylamino)phenyl]quinazolin-4-ylamino}propionic acid

Guidance literature:: With sodium carbonate; at 100 ℃; for 8h; pH=9 - 9.5;

Reference yield:

: 313495-66-8
4-methyl-N-[4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]benzenesulfonamide

: 940352-23-8
2-{2-[4-(toluene-4-sulfonylamino)phenyl]quinazolin-4-ylamino}propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / PCl₅; POCl₃ / 2 h / Heating

2: 66 percent / sodium carbonate / H₂O / 8 h / 100 °C / pH 9 - 9.5

With phosphorus pentachloride; sodium carbonate; trichlorophosphate; In water;
DOI:10.1002/jccs.200700061

Reference yield:

: 37028-94-7
2-[4-(toluene-4-sulfonylamino)benzoylamino]benzoic acid

: 940352-23-8
2-{2-[4-(toluene-4-sulfonylamino)phenyl]quinazolin-4-ylamino}propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / acetic anhydride / 3 h / Heating

2: 69 percent / ammonium acetate / 1 h / 160 - 170 °C

3: 73 percent / PCl₅; POCl₃ / 2 h / Heating

4: 66 percent / sodium carbonate / H₂O / 8 h / 100 °C / pH 9 - 9.5

With ammonium acetate; phosphorus pentachloride; acetic anhydride; sodium carbonate; trichlorophosphate; In water;
DOI:10.1002/jccs.200700061