(3S)-1-[(2S,3S)-2-amino-3-[4-(6-oxo-1,6-dihydropyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine hydrochloride

Base Information

Chemical Name:(3S)-1-[(2S,3S)-2-amino-3-[4-(6-oxo-1,6-dihydropyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine hydrochloride
CAS No.:690256-57-6
Molecular Formula:C₁₉H₂₂FN₃O₂*ClH
Molecular Weight:379.862
Hs Code.:

Synonyms:(3S)-1-[(2S,3S)-2-amino-3-[4-(6-oxo-1,6-dihydropyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine hydrochloride

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Chemical Property of (3S)-1-[(2S,3S)-2-amino-3-[4-(6-oxo-1,6-dihydropyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine hydrochloride

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Technology Process of (3S)-1-[(2S,3S)-2-amino-3-[4-(6-oxo-1,6-dihydropyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine hydrochloride

There total 8 articles about (3S)-1-[(2S,3S)-2-amino-3-[4-(6-oxo-1,6-dihydropyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 876625-74-0
(3S)-1-[(2S,3S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(6-methoxypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine

: 690256-57-6
(3S)-1-[(2S,3S)-2-amino-3-[4-(6-oxo-1,6-dihydropyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine hydrochloride

Guidance literature:: With hydrogenchloride; In water; at 100 ℃; for 48h;

Reference yield:

: 690257-78-4
(R)-3-(3-(4-bromophenyl)acryloyl)-4-phenyloxazolidin-2-one

: 690256-57-6
(3S)-1-[(2S,3S)-2-amino-3-[4-(6-oxo-1,6-dihydropyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper (II) bromide dimethylsulfide / tetrahydrofuran; dimethylsulfide; diethyl ether / 0.5 h / -40 °C

1.2: 15 h / -20 - 20 °C

2.1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / -78 - 0 °C

2.2: 4 h / -78 - 0 °C

3.1: tetramethylguanidinum azide / acetonitrile / 12 h / 20 °C

4.1: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 4.25 h / 0 °C

5.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 12 h / 20 °C

5.2: 12 h / 90 °C

5.3: 12 h / 20 °C

6.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 12 h / 90 °C

7.1: hydrogenchloride / water / 48 h / 100 °C

With hydrogenchloride; lithium hydroxide; copper (II) bromide dimethylsulfide; di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; tetramethylguanidinum azide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dimethylsulfide; diethyl ether; ethanol; dichloromethane; water; toluene; acetonitrile; 6.1: Suzuki Coupling;

Reference yield:

: 690257-82-0
(2R,3S)-2-azido-3-(4-bromophenyl)butanoic acid

: 690256-57-6
(3S)-1-[(2S,3S)-2-amino-3-[4-(6-oxo-1,6-dihydropyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 12 h / 20 °C

1.2: 12 h / 90 °C

1.3: 12 h / 20 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 12 h / 90 °C

3.1: hydrogenchloride / water / 48 h / 100 °C

With hydrogenchloride; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In DMF (N,N-dimethyl-formamide); ethanol; water; toluene; 2.1: Suzuki Coupling;