(2R)-4-cyclohexyl-1-(5-methoxycyclohexa-1,4-dienyl)butan-2-ol

Base Information

• Chemical Name: (2R)-4-cyclohexyl-1-(5-methoxycyclohexa-1,4-dienyl)butan-2-ol
• CAS No.: 795279-36-6
• Molecular Formula: C₁₇H₂₈O₂
• Molecular Weight: 264.408
• Mol file: 795279-36-6.mol

Synonyms:(2R)-4-cyclohexyl-1-(5-methoxycyclohexa-1,4-dienyl)butan-2-ol

Chemical Property of (2R)-4-cyclohexyl-1-(5-methoxycyclohexa-1,4-dienyl)butan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (2R)-4-cyclohexyl-1-(5-methoxycyclohexa-1,4-dienyl)butan-2-ol

There total 1 articles about (2R)-4-cyclohexyl-1-(5-methoxycyclohexa-1,4-dienyl)butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(1S,2R)-4-cyclohexyl-1-propoxy-1-(3-methoxyphenyl)butan-2-ol → (2R)-4-cyclohexyl-1-(5-methoxycyclohexa-1,4-dienyl)butan-2-ol (795279-36-6)

Guidance literature:

With ammonia; lithium; isopropyl alcohol; In tetrahydrofuran; for 2h; Heating;

DOI:10.1016/j.tet.2004.07.044

Reference yield:

(2R)-4-cyclohexyl-1-(5-methoxycyclohexa-1,4-dienyl)butan-2-ol (795279-36-6) → (5R)-7-cyclohexyl-5-hydroxy-3-oxoheptanoic acid methyl ester (120185-82-2)

Guidance literature:

(2R)-4-cyclohexyl-1-(5-methoxycyclohexa-1,4-dienyl)butan-2-ol; With pyridine; ozone; In methanol; dichloromethane; at -78 ℃;

With triphenylphosphine; In methanol; dichloromethane; at 20 ℃; for 1h; Further stages.;

DOI:10.1016/j.tet.2004.07.044

Reference yield:

(2R)-4-cyclohexyl-1-(5-methoxycyclohexa-1,4-dienyl)butan-2-ol (795279-36-6) → (3R,5R)-7-Cyclohexyl-3,5-dihydroxy-heptanoic acid methyl ester (120185-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: O₃; pyridine / methanol; CH₂Cl₂ / -78 °C

1.2: PPh₃ / methanol; CH₂Cl₂ / 1 h / 20 °C

2.1: NaBH₄; Et₂B(OMe) / tetrahydrofuran; methanol / 2 h / -78 °C

With pyridine; sodium tetrahydroborate; diethyl methoxy borane; ozone; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.tet.2004.07.044

Downstream raw materials:

(5R)-7-cyclohexyl-5-hydroxy-3-oxoheptanoic acid methyl ester

(3R,5R)-7-Cyclohexyl-3,5-dihydroxy-heptanoic acid methyl ester

(4R,6R)-6-(2-cyclohexylethyl)-4-hydroxytetrahydropyran-2-one