120185-82-2

Upstream product

• 120185-80-0 (2S,4R)-2-(2-Cyclohexyl-ethyl)-4-methyl-[1,3]dioxane 
• 74590-73-1 1,3-bis(trimethylsiloxy)-1-methoxybuta-1,3-diene 
• 795279-36-6 (2R)-4-cyclohexyl-1-(5-methoxycyclohexa-1,4-dienyl)butan-2-ol 
• 120185-81-1 (R)-7-Cyclohexyl-5-((R)-3-hydroxy-1-methyl-propoxy)-3-oxo-heptanoic acid methyl ester 

Downstream Products

• 86031-05-2 (4R,6R)-6-(2-cyclohexylethyl)-4-hydroxytetrahydropyran-2-one 
• 120185-83-3 (3R,5R)-7-Cyclohexyl-3,5-dihydroxy-heptanoic acid methyl ester 

Relevant academic research and scientific papers

Application of sulfur ylide mediated epoxidations in the asymmetric synthesis of β-hydroxy-δ-lactones. Synthesis of a mevinic acid analogue and (+)-prelactone B

Catalytic and stoichiometric asymmetric sulfur ylide reactions were employed to prepare alkyl-aryl epoxide intermediates in a convergent manner. These epoxides were utilized in efficient syntheses of the mevinic acid analogue 1 and prelactone B. Graphical abstract.

Asymmetric Synthesis via Acetal Templates. 15. The Preparation of Enantiomerically Pure Mevinolin Analogs

An efficient asymmetric synthesis of the hydroxylactone moiety of mevinolin 1 is described.The key step is the TiCl4-catalyzed coupling reaction of acetals 3a and 3b derived from (R)-1,3-butanediol with 1,3-bis(trimethylsilyloxy)-1-methoxybuta-