N-benzyloxycarbonyl-O-t-butyl-L-tyrosyl-α-aminoisobutyrylglycyl-L-phenylalanyl-L-methionine dimethylamide

Base Information

Chemical Name:N-benzyloxycarbonyl-O-t-butyl-L-tyrosyl-α-aminoisobutyrylglycyl-L-phenylalanyl-L-methionine dimethylamide
CAS No.:98607-23-9
Molecular Formula:C₄₃H₅₈N₆O₈S
Molecular Weight:819.035
Hs Code.:

Synonyms:N-benzyloxycarbonyl-O-t-butyl-L-tyrosyl-α-aminoisobutyrylglycyl-L-phenylalanyl-L-methionine dimethylamide

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Chemical Property of N-benzyloxycarbonyl-O-t-butyl-L-tyrosyl-α-aminoisobutyrylglycyl-L-phenylalanyl-L-methionine dimethylamide

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Technology Process of N-benzyloxycarbonyl-O-t-butyl-L-tyrosyl-α-aminoisobutyrylglycyl-L-phenylalanyl-L-methionine dimethylamide

There total 5 articles about N-benzyloxycarbonyl-O-t-butyl-L-tyrosyl-α-aminoisobutyrylglycyl-L-phenylalanyl-L-methionine dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 94847-41-3
hydrochloride of dimethylamide of L-phenylalanyl-L-methionine

: 88498-61-7
N-benzyloxycarbonyl-O-t-butyl-L-tyrosyl-α-aminoisobutyrylglycine

: 98607-23-9
N-benzyloxycarbonyl-O-t-butyl-L-tyrosyl-α-aminoisobutyrylglycyl-L-phenylalanyl-L-methionine dimethylamide

Guidance literature:: With 4-methyl-morpholine; diphenylphosphoranyl azide; In N,N-dimethyl-formamide; for 15h; Ambient temperature;

Reference yield:

: 5545-54-0
N-(benzyloxycarbonyl)-O-(1,1-dimethylethyl)-L-tyrosine

: 98607-23-9
N-benzyloxycarbonyl-O-t-butyl-L-tyrosyl-α-aminoisobutyrylglycyl-L-phenylalanyl-L-methionine dimethylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT), N-methylmorpholine, 2.) N-methylmorpholine / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, RT, 12 h

2: 86 percent / aq. NaOH / propan-2-ol / 12 h / Ambient temperature

3: 82 percent / 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT), N-methylmorpholine (NMM) / CH₂Cl₂ / 16 h / 0 - 20 °C

4: 83 percent / aq. NaOH / ethanol / 2 h / Ambient temperature

5: 89 percent / diphenylphosphoryl azide (DPPA), N-methylmorpholine (NMM) / dimethylformamide / 15 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; diphenylphosphoranyl azide; In ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 98607-21-7
N-benzyloxycarbonyl-O-t-butyl-L-tyrosyl-α-aminoisobutyric acid

: 98607-23-9
N-benzyloxycarbonyl-O-t-butyl-L-tyrosyl-α-aminoisobutyrylglycyl-L-phenylalanyl-L-methionine dimethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT), N-methylmorpholine (NMM) / CH₂Cl₂ / 16 h / 0 - 20 °C

2: 83 percent / aq. NaOH / ethanol / 2 h / Ambient temperature

3: 89 percent / diphenylphosphoryl azide (DPPA), N-methylmorpholine (NMM) / dimethylformamide / 15 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; diphenylphosphoranyl azide; In ethanol; dichloromethane; N,N-dimethyl-formamide;