N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-cyano-2-fluorobenzamide

Base Information

Chemical Name:N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-cyano-2-fluorobenzamide
CAS No.:1217420-11-5
Molecular Formula:C₂₁H₂₅FN₄O₂
Molecular Weight:384.454
Hs Code.:

Synonyms:N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-cyano-2-fluorobenzamide

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Chemical Property of N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-cyano-2-fluorobenzamide

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Technology Process of N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-cyano-2-fluorobenzamide

There total 2 articles about N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-cyano-2-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1140917-46-9
5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-imine

: 146328-87-2
2-fluoro-5-cyanobenzoic acid

: 1217420-11-5
N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-cyano-2-fluorobenzamide

Guidance literature:: 5-cyano-2-fluorobenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 1h;

5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-imine; With triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 335256-12-7
5-cyano-2-fluorobenzoyl chloride

: 1140917-46-9
5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-imine

: 1217420-11-5
N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-cyano-2-fluorobenzamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield: 51.0%

: 558-43-0
2-Methyl-1,2-propanediol

: 1217420-11-5
N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-cyano-2-fluorobenzamide

: 1217403-83-2
N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-cyano-2-(2-hydroxy-2-methylpropoxy)benzamide

Guidance literature:: 2-Methyl-1,2-propanediol; With sodium t-butanolate; In tetrahydrofuran; for 0.166667h;

N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-cyano-2-fluorobenzamide; In tetrahydrofuran; at 20 ℃; for 1h;