methyl 3-(4-(N-methylmethan-3-ylsulfonamido)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylate

Base Information

Chemical Name:methyl 3-(4-(N-methylmethan-3-ylsulfonamido)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylate
CAS No.:1268865-85-5
Molecular Formula:C₂₃H₂₆N₄O₄S
Molecular Weight:454.55
Hs Code.:

Synonyms:methyl 3-(4-(N-methylmethan-3-ylsulfonamido)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylate

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Chemical Property of methyl 3-(4-(N-methylmethan-3-ylsulfonamido)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylate

Chemical Property:

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Technology Process of methyl 3-(4-(N-methylmethan-3-ylsulfonamido)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylate

There total 10 articles about methyl 3-(4-(N-methylmethan-3-ylsulfonamido)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268865-93-5
methyl 3-(4-(methylamino)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylate

: 124-63-0
methanesulfonyl chloride

: 1268865-85-5
methyl 3-(4-(N-methylmethan-3-ylsulfonamido)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 1268865-85-5
methyl 3-(4-(N-methylmethan-3-ylsulfonamido)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 30 °C

2.1: ammonium chloride; iron / water; methanol / 5 h / Reflux

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 20 °C

4.1: phosphorus(V) oxybromide / acetonitrile / Reflux

4.2: pH 7 - 8

5.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 100 °C

6.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

6.2: 3 h / 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

7.2: 3 h / 0 - 20 °C

8.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

8.2: pH 9

9.1: triethylamine / dichloromethane / 3 h / 20 °C

With iron; sodium hydride; potassium carbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; phosphorus(V) oxybromide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1268865-85-5
methyl 3-(4-(N-methylmethan-3-ylsulfonamido)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: thionyl chloride / 3 h / 0 °C / Reflux

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 30 °C

3.1: ammonium chloride; iron / water; methanol / 5 h / Reflux

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 20 °C

5.1: phosphorus(V) oxybromide / acetonitrile / Reflux

5.2: pH 7 - 8

6.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 100 °C

7.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

7.2: 3 h / 20 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

8.2: 3 h / 0 - 20 °C

9.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

9.2: pH 9

10.1: triethylamine / dichloromethane / 3 h / 20 °C

With thionyl chloride; iron; sodium hydride; potassium carbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; phosphorus(V) oxybromide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;