(2S,4S,5S)-1-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>-2-<<(phenylmethoxy)carbonyl>amino>-3-methylbutane

Base Information

Chemical Name:(2S,4S,5S)-1-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>-2-<<(phenylmethoxy)carbonyl>amino>-3-methylbutane
CAS No.:140660-63-5
Molecular Formula:C₃₀H₄₈N₂O₅
Molecular Weight:516.722
Hs Code.:

Synonyms:(2S,4S,5S)-1-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>-2-<<(phenylmethoxy)carbonyl>amino>-3-methylbutane

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Chemical Property of (2S,4S,5S)-1-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>-2-<<(phenylmethoxy)carbonyl>amino>-3-methylbutane

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Technology Process of (2S,4S,5S)-1-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>-2-<<(phenylmethoxy)carbonyl>amino>-3-methylbutane

There total 1 articles about (2S,4S,5S)-1-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>-2-<<(phenylmethoxy)carbonyl>amino>-3-methylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129921-93-3
2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 140660-63-5
(2S,4S,5S)-1-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>-2-<<(phenylmethoxy)carbonyl>amino>-3-methylbutane

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; Yield given. Multistep reaction; 1.) toluene, 70 deg C, 1.5 h, 2.) toluene, reflux, 72 h;
DOI:10.1021/jm00088a007

Reference yield: 99.0%

: 140660-63-5
(2S,4S,5S)-1-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>-2-<<(phenylmethoxy)carbonyl>amino>-3-methylbutane

: 140660-66-8
(2S,4S,5S)-1-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>-2-amino-3-methylbutane

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 18h; under 3040 Torr;
DOI:10.1021/jm00088a007

Reference yield:

: 140660-63-5
(2S,4S,5S)-1-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>-2-<<(phenylmethoxy)carbonyl>amino>-3-methylbutane

: 140660-68-0
(4S,5S)-4-Cyclohexylmethyl-2,2-dimethyl-5-[(S)-3-methyl-2-(propane-2-sulfonylamino)-butyl]-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂ / 10percent Pd/C / ethyl acetate / 18 h / 3040 Torr

2: 91 percent / triethylamine / CH₂Cl₂ / 1.5 h / -10 °C

With hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00088a007