5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-meth-(Z)-ylidene]-6-methyl-heptan-2-one

Base Information

Chemical Name:5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-meth-(Z)-ylidene]-6-methyl-heptan-2-one
CAS No.:656252-28-7
Molecular Formula:C₂₄H₄₀O₃Si
Molecular Weight:404.665
Hs Code.:

Synonyms:5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-meth-(Z)-ylidene]-6-methyl-heptan-2-one

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Chemical Property of 5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-meth-(Z)-ylidene]-6-methyl-heptan-2-one

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Technology Process of 5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-meth-(Z)-ylidene]-6-methyl-heptan-2-one

There total 6 articles about 5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-meth-(Z)-ylidene]-6-methyl-heptan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 386703-32-8
3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-benzyl]-2-methyl-hept-6-en-3-ol

: 656252-28-7
5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-meth-(Z)-ylidene]-6-methyl-heptan-2-one

Guidance literature:: 3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-benzyl]-2-methyl-hept-6-en-3-ol; With pyridine; thionyl chloride; In dichloromethane; at -50 - -30 ℃; for 2.5h;

With palladium diacetate; copper diacetate; oxygen; In N,N-dimethyl acetamide; for 18h;
DOI:10.1021/ja030498f

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 656252-28-7
5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-meth-(Z)-ylidene]-6-methyl-heptan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N; DMF / CH₂Cl₂ / 14 h

2.1: 94 percent / Et₃N; SO₃*py / CH₂Cl₂; dimethylsulfoxide / 1 h / 0 °C

3.1: CeCl₃ / tetrahydrofuran / 1 h / -78 °C

3.2: 88 percent / tetrahydrofuran / 2 h / -78 - 0 °C

4.1: pyridine; SOCl₂ / CH₂Cl₂ / 2.5 h / -50 - -30 °C

4.2: 114 mg / aq. Cu(OAc)2; Pd(OAc)2; O₂ / N,N-dimethyl-acetamide / 18 h

With pyridine; thionyl chloride; cerium(III) chloride; pyridine-SO₃ complex; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 4.2: Wacker oxidation;
DOI:10.1021/ja030498f

Reference yield:

: 656252-26-5
3-but-3-enyl-8-methoxy-6-methyl-isochroman-1-one

: 656252-28-7
5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-meth-(Z)-ylidene]-6-methyl-heptan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: LAH / tetrahydrofuran / 0.5 h / 20 °C

2.1: Et₃N; DMF / CH₂Cl₂ / 14 h

3.1: 94 percent / Et₃N; SO₃*py / CH₂Cl₂; dimethylsulfoxide / 1 h / 0 °C

4.1: CeCl₃ / tetrahydrofuran / 1 h / -78 °C

4.2: 88 percent / tetrahydrofuran / 2 h / -78 - 0 °C

5.1: pyridine; SOCl₂ / CH₂Cl₂ / 2.5 h / -50 - -30 °C

5.2: 114 mg / aq. Cu(OAc)2; Pd(OAc)2; O₂ / N,N-dimethyl-acetamide / 18 h

With pyridine; lithium aluminium tetrahydride; thionyl chloride; cerium(III) chloride; pyridine-SO₃ complex; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 5.2: Wacker oxidation;
DOI:10.1021/ja030498f