6'-chloro-4'-(3-oxobutyl)-1-tosyl-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one

Base Information

Chemical Name:6'-chloro-4'-(3-oxobutyl)-1-tosyl-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one
CAS No.:1609547-84-3
Molecular Formula:C₂₂H₂₇ClN₄O₄S
Molecular Weight:479
Hs Code.:

Synonyms:6'-chloro-4'-(3-oxobutyl)-1-tosyl-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one

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Chemical Property of 6'-chloro-4'-(3-oxobutyl)-1-tosyl-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one

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Technology Process of 6'-chloro-4'-(3-oxobutyl)-1-tosyl-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one

There total 4 articles about 6'-chloro-4'-(3-oxobutyl)-1-tosyl-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1609547-83-2
S-(1-(4-((4,6-dichloropyrimidin-2-yl)amino)-1-tosylpiperidin-4-yl)-5-oxohexan-2-yl)-O-ethyl carbonodithioate

: 1609547-84-3
6'-chloro-4'-(3-oxobutyl)-1-tosyl-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one

Guidance literature:: With 2,6-dimethylpyridine; dilauryl peroxide; In ethyl acetate; Inert atmosphere; Reflux;
DOI:10.1021/ol501104h

Reference yield:

: 1609547-75-2
N-(4-allyl-1-tosylpiperidin-4-yl)-4,6-dichloropyrimidin-2-amine

: 1609547-84-3
6'-chloro-4'-(3-oxobutyl)-1-tosyl-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: dilauryl peroxide / ethyl acetate / Inert atmosphere; Reflux

2: dilauryl peroxide; 2,6-dimethylpyridine / ethyl acetate / Inert atmosphere; Reflux

With 2,6-dimethylpyridine; dilauryl peroxide; In ethyl acetate;
DOI:10.1021/ol501104h

Reference yield:

: 33439-27-9
N-tosyl-4-piperidone

: 1609547-84-3
6'-chloro-4'-(3-oxobutyl)-1-tosyl-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonia / methanol / 0.25 h / 20 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 72 h / 90 °C / Inert atmosphere; Sealed tube

3.1: dilauryl peroxide / ethyl acetate / Inert atmosphere; Reflux

4.1: dilauryl peroxide; 2,6-dimethylpyridine / ethyl acetate / Inert atmosphere; Reflux

With 2,6-dimethylpyridine; dilauryl peroxide; ammonia; triethylamine; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/ol501104h