1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6,7-diphenyl-1H-pteridine-2,4-dione

Base Information

• Chemical Name: 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6,7-diphenyl-1H-pteridine-2,4-dione
• CAS No.: 196872-73-8
• Molecular Formula: C₄₄H₃₈N₄O₇
• Molecular Weight: 734.808

Synonyms:1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6,7-diphenyl-1H-pteridine-2,4-dione

Chemical Property of 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6,7-diphenyl-1H-pteridine-2,4-dione

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Technology Process of 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6,7-diphenyl-1H-pteridine-2,4-dione

There total 2 articles about 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6,7-diphenyl-1H-pteridine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

JUBVOR (35777-74-3) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6,7-diphenyl-1H-pteridine-2,4-dione (196872-73-8)

Guidance literature:

With pyridine; for 4h; Ambient temperature;

DOI:10.1002/hlca.19970800611

Reference yield:

1-[O3,O5-bis-(4-methyl-benzoyl)-β-D-erythro-2-deoxy-pentofuranosyl]-6,7-diphenyl-1H-pteridine-2,4-dione (35777-66-3) → 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6,7-diphenyl-1H-pteridine-2,4-dione (196872-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOMe / methanol / Ambient temperature

2: 91 percent / pyridine / 4 h / Ambient temperature

With pyridine; sodium methylate; In methanol;

DOI:10.1002/hlca.19970800611

Reference yield: 81.0%

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6,7-diphenyl-1H-pteridine-2,4-dione (196872-73-8) → Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-6,7-diphenyl-3,4-dihydro-2H-pteridin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:

With 1H-tetrazole; In dichloromethane; acetonitrile; for 4h; Ambient temperature;

DOI:10.1002/hlca.19970800611

upstream raw materials:

JUBVOR

4,4'-dimethoxytrityl chloride

1-[O³,O⁵-bis-(4-methyl-benzoyl)-β-D-erythro-2-deoxy-pentofuranosyl]-6,7-diphenyl-1H-pteridine-2,4-dione

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