trans-4-Fluoroproline

Base Information

Chemical Name:trans-4-Fluoroproline
CAS No.:2507-61-1
Molecular Formula:C₅H₈FNO₂
Molecular Weight:133.122
Hs Code.:2933998090
Mol file:2507-61-1.mol

Synonyms:TRANS-4-FLUOROPROLINE;(2S,4R)-4-Fluoropyrrolidinium-2-carboxylate;(2S,4R)-4-FLUOROPYRROLIDIN-1-IUM-2-CARBOXYLATE

Suppliers and Price of trans-4-Fluoroproline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S,4R)-4-Fluoropyrrolidine-2-carboxylicAcid
100mg
$ 165.00

TCI Chemical
trans-4-Fluoro-L-proline >98.0%(HPLC)
50mg
$ 98.00

SynQuest Laboratories
trans-4-Fluoro-L-proline
250 mg
$ 448.00

SynQuest Laboratories
trans-4-Fluoro-L-proline
100 mg
$ 256.00

Crysdot
(2S,4R)-4-Fluoropyrrolidine-2-carboxylicacid 95+%
5g
$ 223.00

Crysdot
(2S,4R)-4-Fluoropyrrolidine-2-carboxylicacid 95+%
1g
$ 74.00

Crysdot
(2S,4R)-4-Fluoropyrrolidine-2-carboxylicacid 95+%
10g
$ 342.00

Chem-Impex
trans-4-Fluoro-L-proline,97%(HPLC) 97%(HPLC)
250MG
$ 134.40

Chem-Impex
trans-4-Fluoro-L-proline,≥97%(HPLC) ≥97%(HPLC)
5G
$ 1974.34

Chem-Impex
trans-4-Fluoro-L-proline,97%(HPLC) 97%(HPLC)
1G
$ 436.80

Total 49 raw suppliers

Chemical Property of trans-4-Fluoroproline

Chemical Property:

Appearance/Colour:Colourless solid
Vapor Pressure:0.00271mmHg at 25°C
Melting Point:264°C(lit.)
Refractive Index:1.472
Boiling Point:265.108 °C at 760 mmHg
PKA:1.88±0.40(Predicted)
Flash Point:114.133 °C
PSA：49.33000
Density:1.309 g/cm³
LogP:0.09980
Storage Temp.:Store at RT.
XLogP3:-1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:133.05390666
Heavy Atom Count:9
Complexity:123

Purity/Quality:

99% ^*data from raw suppliers

(2S,4R)-4-Fluoropyrrolidine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-36
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C[NH2+]C1C(=O)[O-])F
Isomeric SMILES:C1[C@H](C[NH2+][C@@H]1C(=O)[O-])F

Technology Process of trans-4-Fluoroproline

There total 9 articles about trans-4-Fluoroproline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 156046-04-7
(5S,7R)-7-fluoro-2,2-bis(trifluoromethyl)-1-aza-3-oxabicyclo<3.3.0>octan-4-one

: 2438-57-5,2507-61-1,7553-49-3,21156-44-5,21156-75-2,60828-35-5,131176-02-8,913820-71-0
(2S,4R)-4-fluoropyrrolidine-2-carboxylic acid

Guidance literature:: With water; In isopropyl alcohol; Ambient temperature;
DOI:10.1016/0022-1139(93)02907-V

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 2438-57-5,2507-61-1,7553-49-3,21156-44-5,21156-75-2,60828-35-5,131176-02-8,913820-71-0
(2S,4R)-4-fluoropyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / Et₃N / CHCl₃ / 0 °C

2: 1.) PPh₃, DEAD, PhCO₂H; 2.) KOH / 1.) toluene; 2.) MeOH

3: 63 percent / DAST / CH₂Cl₂ / -78 deg C to r.t.

4: 99 percent / LiOH / acetonitrile; H₂O / Ambient temperature

5: TFA / CH₂Cl₂

With potassium hydroxide; lithium hydroxide; triethylamine; triphenylphosphine; 4,4'-diaminostilbene-2,2'-disulfonic acid; benzoic acid; trifluoroacetic acid; diethylazodicarboxylate; In dichloromethane; chloroform; water; acetonitrile;
DOI:10.1016/S0040-4039(97)10793-6