N-(5-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-morpholinoacetamide

Base Information

Chemical Name:N-(5-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-morpholinoacetamide
CAS No.:1430724-93-8
Molecular Formula:C₂₈H₂₄F₂N₆O₂
Molecular Weight:514.534
Hs Code.:

Synonyms:N-(5-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-morpholinoacetamide

Suppliers and Price of N-(5-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-morpholinoacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(5-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-morpholinoacetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(5-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-morpholinoacetamide

There total 12 articles about N-(5-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-morpholinoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 3235-69-6
morpholin-4-ylacetic acid

: 1430727-70-0
5-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-amine

: 1430724-93-8
N-(5-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-morpholinoacetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 12h;

Reference yield:

: 18242-39-2
3,5-dinitrobromobenzene

: 1430724-93-8
N-(5-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-morpholinoacetamide

Guidance literature:: Multi-step reaction with 10 steps

1: acetic acid; iron / acetic acid / 0.5 h / 90 °C

2: 0.5 h / 0 - 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

5: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

6: ammonium chloride; zinc / water; tetrahydrofuran / 6 h / 20 °C

7: 0.5 h / 100 °C

8: caesium carbonate; copper(I) oxide / N,N-dimethyl-formamide; methanol / 48 h / 90 °C

9: sodium hydroxide / water; ethanol / 5 h / 85 °C

10: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h

With copper(I) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; palladium 10% on activated carbon; hydrogen; iron; sodium carbonate; ammonium chloride; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 99-65-0
meta-dinitrobenzene

: 1430724-93-8
N-(5-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-morpholinoacetamide

Guidance literature:: Multi-step reaction with 11 steps

1: sulfuric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / 12.5 h / 0 - 20 °C

2: acetic acid; iron / acetic acid / 0.5 h / 90 °C

3: 0.5 h / 0 - 20 °C

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

6: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

7: ammonium chloride; zinc / water; tetrahydrofuran / 6 h / 20 °C

8: 0.5 h / 100 °C

9: caesium carbonate; copper(I) oxide / N,N-dimethyl-formamide; methanol / 48 h / 90 °C

10: sodium hydroxide / water; ethanol / 5 h / 85 °C

11: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h

With copper(I) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; palladium 10% on activated carbon; hydrogen; iron; sodium carbonate; ammonium chloride; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;