(E)-methyl 7-oxo-7-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenylamino)heptanoate

Base Information

Chemical Name:(E)-methyl 7-oxo-7-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenylamino)heptanoate
CAS No.:1133966-21-8
Molecular Formula:C₂₈H₂₈N₄O₃S
Molecular Weight:500.621
Hs Code.:

Synonyms:(E)-methyl 7-oxo-7-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenylamino)heptanoate

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Chemical Property of (E)-methyl 7-oxo-7-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenylamino)heptanoate

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Technology Process of (E)-methyl 7-oxo-7-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenylamino)heptanoate

There total 9 articles about (E)-methyl 7-oxo-7-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenylamino)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 20291-40-1
7-methoxy-7-oxoheptanoic acid

: 1133966-20-7
(E)-2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzenamine

: 1133966-21-8
(E)-methyl 7-oxo-7-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenylamino)heptanoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 123 ℃; for 6h; Inert atmosphere;

Reference yield:

: 886230-75-7
(Ε)-6-nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)indazole

: 1133966-21-8
(E)-methyl 7-oxo-7-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenylamino)heptanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium chloride; iron / ethanol; water / 2 h / 50 °C

2.1: hydrogenchloride; sodium nitrite; acetic acid / water / 0 °C

2.2: 2 h / 0 °C

3.1: sodium hydroxide / ISOPROPYLAMIDE / 155 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / water; methanol / 2 h / Reflux

4.2: pH 10

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 6 h / 123 °C / Inert atmosphere

With hydrogenchloride; dmap; iron; ammonium chloride; toluene-4-sulfonic acid; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; sodium nitrite; In methanol; ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;

Reference yield:

: 1141-88-4
2-Aminophenyl disulfide

: 1133966-21-8
(E)-methyl 7-oxo-7-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenylamino)heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; zinc / ethanol / 0.5 h

2.1: sodium hydroxide / ISOPROPYLAMIDE / 155 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / water; methanol / 2 h / Reflux

3.2: pH 10

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 6 h / 123 °C / Inert atmosphere

With hydrogenchloride; dmap; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; zinc; In methanol; ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;