886230-75-7

Basic information

• Product Name: (E)-6-Nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
• Synonyms: (E)-6-Nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole;(E)-6-Nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl);(E)-6-nitro-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole;6-nitro-3-(E)-2-pyridin-2-yl-vinyl)-1- (tetrahydropyran-2-yl)-1H-indazole;6-nitro-3-[(E)-2-(2-pyridyl)vinyl]-1-tetrahydropyran-2-yl-indazol e;1H-Indazole, 6-nitro-3-[(1E)-2-(2-pyridinyl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-;Axitinib Intermediate 2
• CAS NO: 886230-75-7
• Molecular Formula: C₁₉H₁₈N₄O₃
• Molecular Weight: 350.37
• EINECS: 1592732-453-0
• Product Categories: Intermediate of Axitinib
• Mol File: 886230-75-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 570.9±50.0 °C(Predicted)
• Appearance: /
• Density: 1.36
• Storage Temp.: 2-8°C
• PKA: 4.20±0.10(Predicted)
• CAS DataBase Reference: (E)-6-Nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-6-Nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole(886230-75-7)
• EPA Substance Registry System: (E)-6-Nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole(886230-75-7)

Safety Data

• Hazardous Substances Data: 886230-75-7(Hazardous Substances Data)

Usage

General Description

"(E)-6-Nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole" is a complex chemical compound. Its structure indicates that it belongs to the class of organic compounds known as indazoles, which are polycyclic aromatic compounds containing an indazole moiety. Indazole is a pyrazole fused to a benzene ring. The compound also contains a nitro group, an ethenyl group attached to a pyridine ring, and a tetrahydropyran ring fused to the indazole. It is likely to be a synthetic compound and could be used in various chemical reactions due to its complex molecular structure. However, specific properties, uses, and safety information are not readily available and would depend on further testing and research.

Upstream product

• 100-69-6 2-vinylpyridine 
• 886230-74-6 3-iodo-6-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole 
• 7597-18-4 6-nitroindazole 
• 70315-70-7 3-iodo-6-nitro-1H-indazole 
• 315203-37-3 6-nitro-1H-indazole-3-carboxaldehyde 
• 73870-22-1 triphenyl(pyridine-2-ylmethyl)phosphonium bromide 
• 1339955-82-6 3-bromo-6-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole 
• 110-87-2 3,4-dihydro-2H-pyran 
• 150187-67-0 6-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole 

Downstream Products

• 1012060-43-3 methyl 6-(2-(1-(tetrahydro-2H-pyran-2-yl)-3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamido)hexanoate 
• 1012060-44-4 methyl 6-(2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamido)hexanoate 
• 1012056-56-2 N-(5-(hydroxycarbamoyl)pentyl)-2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamide 
• 1133966-04-7 (E)-methyl 5-(2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)phenoxy)pentanoate 
• 1133966-05-8 (E)-methyl 5-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenoxy)pentanoate 
• 1133966-14-9 (E)-2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)benzenamine 
• 1133966-15-0 (E)-methyl 5-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenylamino)pentanoate 
• 1133966-18-3 (E)-ethyl 6-oxo-6-(2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)phenylamino)hexanoate 
• 1133966-19-4 (E)-ethyl 6-oxo-6-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenylamino)hexanoate 
• 1133966-20-7 (E)-2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzenamine 
• 1133966-21-8 (E)-methyl 7-oxo-7-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenylamino)heptanoate 
• 885126-35-2 (E)-N-methyl-2-{[3-(2-(pyridin-2-yl)ethenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl]thio}benzamide 
• 319460-85-0 axitinib 
• 886230-76-8 (Ε)-6-amino-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)indazole 

Relevant articles and documents

Axitinib intermediate synthesis method

The invention relates to an axitinib intermediate synthesis method, and belongs to the field of chemical synthesis, wherein a target compound is obtained through a Vilsmeier reaction, pyranyl protection, a wittig reaction, a reduction reaction and an iodo reaction. According to the present invention, the palladium catalytic reaction is replaced with the wittig reaction, such that the use of the expensive palladium catalyst can be avoided, the post-treatment can be conveniently performed, and the production cost is saved.

A process for the preparation of intermediates axi for Nepal the preparation and application of axi for Nepal

The invention relates to a method for preparing an intermediate of axitinib and application of the intermediate in preparation of axitinib. The preparation method for the intermediate of axitinib 3-iodine-6-nitro-1-(teralin-2H-pyran-2-base)-1H-indazole comprises the following steps that 6-nitroindazole and 3,4-dihydro-2H-pyran react under the action of catalyst so as to protect perssad tetralin-2H-pyran-2-base at N-H site, and the key intermediate with high yield is obtained through iodination at site 3. The application of the intermediate in preparation of axitinib is as follows: Heck coupled reaction is carried out on the intermediate and 2-vinyl pyridine, then nitro reduction and diazo-reaction for iodination are sequentially carried out, finally, the axitinib is obtained after docking of 2-sulfydryl-N-methyl benzamide and deprotection. The related main initial raw materials are easy to purchase in markets, and the method has high yield and high molecule economic efficiency, is efficient and environment-friendly, and is suitable for industrial mass production.

VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY

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