4-(2-Methoxyethoxy)benzoic acid

Base Information

• Chemical Name: 4-(2-Methoxyethoxy)benzoic acid
• CAS No.: 27890-92-2
• Molecular Formula: C10H12 O4
• Molecular Weight: 196.203
• Hs Code.: 2918990090
• European Community (EC) Number: 837-755-8
• DSSTox Substance ID: DTXSID90424534
• Wikidata: Q82237157
• Mol file: 27890-92-2.mol

Synonyms:4-(2-methoxyethoxy)benzoic acid;27890-92-2;4-(2-Methoxy-ethoxy)-benzoic acid;4-(2-Methoxyethoxy)-benzoic acid;4-Methoxyethoxybenzoic Acid;4-(2-methoxyethoxy)benzoicacid;SCHEMBL2741522;DTXSID90424534;4-(2-methoxyethoxyl)benzoic acid;YBICPDGCVIUHNA-UHFFFAOYSA-N;4-(2-methoxy-ethoxy)benzoic acid;CBA89092;MFCD07187813;STL066190;AKOS000155442;BP-20576;BS-27734;FT-0677915;EN300-74449;C78119;A876845;AN-329/43341640;A1-02722;F3191-0224;Z223645188;4-(2-Methoxyethoxy)benzoic acid4-(2-Methoxyethoxy)benzoic acid

Chemical Property of 4-(2-Methoxyethoxy)benzoic acid

Chemical Property:

• Vapor Pressure: 4.35E-05mmHg at 25°C
• Refractive Index: 1.527
• Boiling Point: 336.6°Cat760mmHg
• Flash Point: 132.6°C
• PSA: 55.76000
• Density: 1.186g/cm³
• LogP: 1.41000
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 196.07355886
• Heavy Atom Count: 14
• Complexity: 173

Purity/Quality:

97% ^*data from raw suppliers

4-(2-Methoxy-ethoxy)-benzoicacid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOC1=CC=C(C=C1)C(=O)O

Technology Process of 4-(2-Methoxyethoxy)benzoic acid

There total 5 articles about 4-(2-Methoxyethoxy)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methyl 4-(2-methoxyethoxy)benzoate (60893-68-7) → 4-(2-methoxy-ethoxy)-benzoic acid (27890-92-2)

Guidance literature:

With ethanol; potassium hydroxide; for 1h; Reflux;

Reference yield: 55.0%

2-Bromoethyl methyl ether (6482-24-2) + 4-hydroxy-benzoic acid (99-96-7) → 4-(2-methoxy-ethoxy)-benzoic acid (27890-92-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 44h; Inert atmosphere; Reflux;

Reference yield:

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → 4-(2-methoxy-ethoxy)-benzoic acid (27890-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 10 - 28 °C

2: potassium hydroxide; ethanol / 1 h / Reflux

With ethanol; di-isopropyl azodicarboxylate; triphenylphosphine; potassium hydroxide; In tetrahydrofuran;

upstream raw materials:

methyl 4-hydroxylbenzoate

2-Bromoethyl methyl ether

methyl 4-(2-methoxyethoxy)benzoate

4-hydroxy-benzoic acid

Downstream raw materials:

C₂₇H₃₈N₂O₆

[4-(2-methoxyethoxy)phenyl]methanol

4-(2-methoxyethoxy)benzyl 4-methylbenzenesulfonate

4-{(1E)-3-[(6-chlorohexyl)oxy]-3-oxoprop-1-enyl}phenyl 4-(2-methoxyethoxy)benzoate