(S)-2-((S)-2-(4-bromophenyl)-N-methyl-2-((R)-2,4,6-triisopropylphenylsulfinamido)acetamido)-N,N-diisopropyl-3,3-dimethylbutanamide

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Chemical Name:(S)-2-((S)-2-(4-bromophenyl)-N-methyl-2-((R)-2,4,6-triisopropylphenylsulfinamido)acetamido)-N,N-diisopropyl-3,3-dimethylbutanamide
CAS No.:1429442-56-7
Molecular Formula:C₃₆H₅₆BrN₃O₃S
Molecular Weight:690.829
Hs Code.:

Synonyms:(S)-2-((S)-2-(4-bromophenyl)-N-methyl-2-((R)-2,4,6-triisopropylphenylsulfinamido)acetamido)-N,N-diisopropyl-3,3-dimethylbutanamide

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Chemical Property of (S)-2-((S)-2-(4-bromophenyl)-N-methyl-2-((R)-2,4,6-triisopropylphenylsulfinamido)acetamido)-N,N-diisopropyl-3,3-dimethylbutanamide

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Technology Process of (S)-2-((S)-2-(4-bromophenyl)-N-methyl-2-((R)-2,4,6-triisopropylphenylsulfinamido)acetamido)-N,N-diisopropyl-3,3-dimethylbutanamide

There total 9 articles about (S)-2-((S)-2-(4-bromophenyl)-N-methyl-2-((R)-2,4,6-triisopropylphenylsulfinamido)acetamido)-N,N-diisopropyl-3,3-dimethylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1429442-30-7
(R)-N-(4-bromobenzylidene)-2,4,6-triisopropylbenzenesulfinamide

: 1429442-55-6
(S)-N,N-diisopropyl-3,3-dimethyl-2-(N-methylformamido)butanamide

: 1429442-56-7
(S)-2-((S)-2-(4-bromophenyl)-N-methyl-2-((R)-2,4,6-triisopropylphenylsulfinamido)acetamido)-N,N-diisopropyl-3,3-dimethylbutanamide

Guidance literature:: With lithium diisopropyl amide; In toluene; at -78 ℃; diastereoselective reaction;
DOI:10.1021/ja402647m

Reference yield:

: 630-19-3
pivalaldehyde

: 1429442-56-7
(S)-2-((S)-2-(4-bromophenyl)-N-methyl-2-((R)-2,4,6-triisopropylphenylsulfinamido)acetamido)-N,N-diisopropyl-3,3-dimethylbutanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: titanium (IV) ethoxide / tetrahydrofuran / 16 h / 20 °C

2.1: lithium diisopropyl amide / toluene / -78 °C

3.1: hydrogenchloride / methanol; 1,4-dioxane / 18 h / 20 °C

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 °C

4.2: 0.25 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 °C

5.2: 0.5 h

6.1: lithium diisopropyl amide / toluene / -78 °C

With hydrogenchloride; titanium (IV) ethoxide; sodium hydride; 1,1'-carbonyldiimidazole; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/ja402647m

Reference yield:

: (R)-N-(2,2-dimethylpropylidene)-2-methylpropane-2-sulfinamide

: 1429442-56-7
(S)-2-((S)-2-(4-bromophenyl)-N-methyl-2-((R)-2,4,6-triisopropylphenylsulfinamido)acetamido)-N,N-diisopropyl-3,3-dimethylbutanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / toluene / -78 °C

2.1: hydrogenchloride / methanol; 1,4-dioxane / 1 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 °C

3.2: 0.25 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 °C

4.2: 0.5 h

5.1: lithium diisopropyl amide / toluene / -78 °C

With hydrogenchloride; sodium hydride; 1,1'-carbonyldiimidazole; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/ja402647m