L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine benzyl ester

Base Information

Chemical Name:L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine benzyl ester
CAS No.:173918-09-7
Molecular Formula:C₄₅H₇₂N₄O₁₃
Molecular Weight:877.086
Hs Code.:

Synonyms:L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine benzyl ester

Suppliers and Price of L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine benzyl ester

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Technology Process of L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine benzyl ester

There total 9 articles about L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine benzyl ester

: 173918-09-7
L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine benzyl ester

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran; at -15 - 20 ℃; for 24.25h;
DOI:10.1055/s-0029-1216837

Reference yield:

: 20312-37-2,498-36-2
(R)-2-hydroxy-4-methylpentanoic acid

: 173918-09-7
L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0 - 20 °C

2.1: triethylamine / toluene / 0.17 h / 20 °C

2.2: 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C

4.1: triethylamine / toluene / 0.17 h / 20 °C

4.2: 20 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2019.01.007

Reference yield:

: 173918-07-5
L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine benzyl ester

: 173918-09-7
L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C

2.1: triethylamine / toluene / 0.17 h / 20 °C

2.2: 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; toluene;
DOI:10.1016/j.bmcl.2019.01.007