L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine benzyl ester

Base Information

• Chemical Name: L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine benzyl ester
• CAS No.: 173918-07-5
• Molecular Formula: C₃₂H₅₄N₂O₇Si
• Molecular Weight: 606.875
• Mol file: 173918-07-5.mol

Synonyms:L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine benzyl ester

Chemical Property of L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine benzyl ester

There total 9 articles about L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

L-O-leucine-D-alanine benzyl ester (173918-06-4) + L-OTBDMS-valine-L-valine-OH → L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine benzyl ester (173918-07-5)

Guidance literature:

L-OTBDMS-valine-L-valine-OH; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at -15 ℃; for 0.75h;

L-O-leucine-D-alanine benzyl ester; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1055/s-0029-1216837

Reference yield: 90.0%

C16H23NO4 + L-OTBDMS-valine-L-valine-OH → L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine benzyl ester (173918-07-5)

Guidance literature:

L-OTBDMS-valine-L-valine-OH; With triethylamine; In toluene; at 20 ℃; for 0.166667h;

C₁₆H₂₃NO₄; With dmap; 4-methyl-benzoyl chloride; In toluene; at 20 ℃;

DOI:10.1016/j.bmcl.2019.01.007

Reference yield:

(R)-2-hydroxy-4-methylpentanoic acid (20312-37-2,498-36-2) → L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine benzyl ester (173918-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0 - 20 °C

2.1: triethylamine / toluene / 0.17 h / 20 °C

2.2: 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In toluene; acetonitrile;

DOI:10.1016/j.bmcl.2019.01.007

upstream raw materials:

L-O-leucine-D-alanine benzyl ester

(R)-2-hydroxy-4-methylpentanoic acid

D-alanine benzyl ester p-toluenesulphonate salt

(S)-2-Hydroxy-3-methylbutanoic acid

Downstream raw materials:

L-O-valine-L-valine-D-O-leucine-D-alanine benzyl ester

L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine benzyl ester

L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-D-O-leucine-D-alanine benzyl ester