4-(3-acrylamidophenoxy)-2-(3-methoxyphenylamino)-pyrimidine-5-carboxylic acid phenylamide

Base Information

Chemical Name:4-(3-acrylamidophenoxy)-2-(3-methoxyphenylamino)-pyrimidine-5-carboxylic acid phenylamide
CAS No.:1202758-07-3
Molecular Formula:C₂₇H₂₃N₅O₄
Molecular Weight:481.511
Hs Code.:

Synonyms:4-(3-acrylamidophenoxy)-2-(3-methoxyphenylamino)-pyrimidine-5-carboxylic acid phenylamide

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Chemical Property of 4-(3-acrylamidophenoxy)-2-(3-methoxyphenylamino)-pyrimidine-5-carboxylic acid phenylamide

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Technology Process of 4-(3-acrylamidophenoxy)-2-(3-methoxyphenylamino)-pyrimidine-5-carboxylic acid phenylamide

There total 8 articles about 4-(3-acrylamidophenoxy)-2-(3-methoxyphenylamino)-pyrimidine-5-carboxylic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202760-12-0
C₂₄H₂₁N₅O₃

: 814-68-6,25189-84-8
acryloyl chloride

: 1202758-07-3
4-(3-acrylamidophenoxy)-2-(3-methoxyphenylamino)-pyrimidine-5-carboxylic acid phenylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -70 ℃; for 0.0833333h; Inert atmosphere;

Reference yield:

: 1202760-10-8
C₂₃H₂₄N₄O₆S

: 1202758-07-3
4-(3-acrylamidophenoxy)-2-(3-methoxyphenylamino)-pyrimidine-5-carboxylic acid phenylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 3 h / 50 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / -70 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1202760-08-4
C₁₇H₁₉N₃O₅S

: 1202758-07-3
4-(3-acrylamidophenoxy)-2-(3-methoxyphenylamino)-pyrimidine-5-carboxylic acid phenylamide

Guidance literature:: Multi-step reaction with 5 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / acetonitrile / 0 - 20 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

3: 3 h / 50 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / -70 °C / Inert atmosphere

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane; acetonitrile;