diethyl {2-[4-(2,4-difluorophenyl)-1,2,3-triazol-1-yl]acetamido}-methylphosphonate

Base Information

Chemical Name:diethyl {2-[4-(2,4-difluorophenyl)-1,2,3-triazol-1-yl]acetamido}-methylphosphonate
CAS No.:1621174-68-2
Molecular Formula:C₁₅H₁₉F₂N₄O₄P
Molecular Weight:388.311
Hs Code.:

Synonyms:diethyl {2-[4-(2,4-difluorophenyl)-1,2,3-triazol-1-yl]acetamido}-methylphosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl {2-[4-(2,4-difluorophenyl)-1,2,3-triazol-1-yl]acetamido}-methylphosphonate

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Technology Process of diethyl {2-[4-(2,4-difluorophenyl)-1,2,3-triazol-1-yl]acetamido}-methylphosphonate

There total 3 articles about diethyl {2-[4-(2,4-difluorophenyl)-1,2,3-triazol-1-yl]acetamido}-methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1621174-60-4
diethyl (2-azidoacetamido)-methylphosphonate

: 302912-34-1
2,4-difluoroethynylbenzene

: 1621174-68-2
diethyl {2-[4-(2,4-difluorophenyl)-1,2,3-triazol-1-yl]acetamido}-methylphosphonate

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In ethanol; water; at 40 - 45 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1002/ardp.201300468

Reference yield:

: 17544-66-0
diethyl-[(2-chloroacetylamino)methyl]phosphonate

: 1621174-68-2
diethyl {2-[4-(2,4-difluorophenyl)-1,2,3-triazol-1-yl]acetamido}-methylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; sodium azide / toluene / 4 h / 90 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / ethanol; water / 0.17 h / 40 - 45 °C / Microwave irradiation

With sodium azide; copper(ll) sulfate pentahydrate; tetrabutylammomium bromide; sodium L-ascorbate; In ethanol; water; toluene; 2: |Huisgen Cycloaddition;
DOI:10.1002/ardp.201300468

Reference yield:

: 50917-72-1
aminomethylphosphonic acid diethyl ester

: 1621174-68-2
diethyl {2-[4-(2,4-difluorophenyl)-1,2,3-triazol-1-yl]acetamido}-methylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / toluene / 0 - 20 °C

2: tetrabutylammomium bromide; sodium azide / toluene / 4 h / 90 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / ethanol; water / 0.17 h / 40 - 45 °C / Microwave irradiation

With sodium azide; copper(ll) sulfate pentahydrate; tetrabutylammomium bromide; potassium carbonate; sodium L-ascorbate; In ethanol; water; toluene; 3: |Huisgen Cycloaddition;
DOI:10.1002/ardp.201300468