tert-Butyl-[(2R,3R,5R)-5-(3-methoxymethoxy-propyl)-3-methyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane

Base Information

Chemical Name:tert-Butyl-[(2R,3R,5R)-5-(3-methoxymethoxy-propyl)-3-methyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane
CAS No.:202392-41-4
Molecular Formula:C₂₇H₄₀O₄Si
Molecular Weight:456.698
Hs Code.:

Synonyms:tert-Butyl-[(2R,3R,5R)-5-(3-methoxymethoxy-propyl)-3-methyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane

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Chemical Property of tert-Butyl-[(2R,3R,5R)-5-(3-methoxymethoxy-propyl)-3-methyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane

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Technology Process of tert-Butyl-[(2R,3R,5R)-5-(3-methoxymethoxy-propyl)-3-methyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane

There total 9 articles about tert-Butyl-[(2R,3R,5R)-5-(3-methoxymethoxy-propyl)-3-methyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 107-30-2
chloromethyl methyl ether

: 202392-40-3
3-[(2R,4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-methyl-tetrahydro-furan-2-yl]-propan-1-ol

: 202392-41-4
tert-Butyl-[(2R,3R,5R)-5-(3-methoxymethoxy-propyl)-3-methyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 12h;
DOI:10.1055/s-1997-1075

Reference yield:

: 112837-17-9
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

: 202392-41-4
tert-Butyl-[(2R,3R,5R)-5-(3-methoxymethoxy-propyl)-3-methyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / imidazole / dimethylformamide / 2 h / 25 °C

2: 98 percent / diethyl ether / 0.5 h / -30 °C

3: DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

4: pyridine / 16 h / 25 °C

5: BF₃*OEt₂ / CH₂Cl₂ / 2 h / -78 °C

6: 1.) BH₃*THF; 2.) aq. NaOH, H₂O₂ / 1.) THF, 0 deg C, 1 h; 2.) THF, 0 deg C, 1 h

7: 97 percent / iPr₂NEt / CH₂Cl₂ / 12 h / 25 °C

With pyridine; 1H-imidazole; sodium hydroxide; borane-THF; boron trifluoride diethyl etherate; dihydrogen peroxide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-1997-1075

Reference yield:

: 106757-56-6
(Z)-(-)-methyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate

: 202392-41-4
tert-Butyl-[(2R,3R,5R)-5-(3-methoxymethoxy-propyl)-3-methyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 8 steps

1: 97 percent / CSA / 3 h / 25 °C

2: 92 percent / imidazole / dimethylformamide / 2 h / 25 °C

3: 98 percent / diethyl ether / 0.5 h / -30 °C

4: DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

5: pyridine / 16 h / 25 °C

6: BF₃*OEt₂ / CH₂Cl₂ / 2 h / -78 °C

7: 1.) BH₃*THF; 2.) aq. NaOH, H₂O₂ / 1.) THF, 0 deg C, 1 h; 2.) THF, 0 deg C, 1 h

8: 97 percent / iPr₂NEt / CH₂Cl₂ / 12 h / 25 °C

With pyridine; 1H-imidazole; sodium hydroxide; borane-THF; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; dihydrogen peroxide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-1997-1075