3-[5,7-dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanenitrile

Base Information

Chemical Name:3-[5,7-dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanenitrile
CAS No.:256424-06-3
Molecular Formula:C₂₁H₂₀N₂O₄
Molecular Weight:364.401
Hs Code.:

Synonyms:3-[5,7-dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanenitrile

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Chemical Property of 3-[5,7-dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanenitrile

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Technology Process of 3-[5,7-dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanenitrile

There total 5 articles about 3-[5,7-dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 107-13-1,25014-41-9
acrylonitrile

: 190774-12-0
5,7-dimethoxy-3-(4-methoxyphenyl)-1,2-dihydro-2-quinolinone

: 256424-06-3
3-[5,7-dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanenitrile

Guidance literature:: With N-benzyl-trimethylammonium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm010978m

Reference yield:

: 10272-07-8
3.5-dimethoxyaniline

: 256424-06-3
3-[5,7-dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 82 percent / toluene / 1 h / 20 °C

2.1: POCl₃ / -30 - 75 °C

2.2: 22 percent / aq. AcOH / 3 h / Heating

3.1: 63 percent / Triton B / dimethylformamide / 2 h / 20 °C

With N-benzyl-trimethylammonium hydroxide; trichlorophosphate; In N,N-dimethyl-formamide; toluene; 3.1: Michael addition;
DOI:10.1021/jm010978m

Reference yield:

: 122172-22-9,29969-62-8
ethyl 2-(4-methoxyphenyl)-2-formyl acetate

: 256424-06-3
3-[5,7-dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / polyphosphoric acid trimethylsilyl ester / 1 h / 100 °C

2: 63 percent / Triton B / dimethylformamide / 2 h / 20 °C

With polyphosphoric acid trimethylsilyl ester; N-benzyl-trimethylammonium hydroxide; In N,N-dimethyl-formamide; 2: Michael addition;
DOI:10.1021/jm010978m