Pyrazine, 2-(2-(4-bromo-1-methyl-2-(methylthio)-1H-imidazol-5-yl)-1-propenyl)-5-methyl-, (E)-

Base Information

Chemical Name:Pyrazine, 2-(2-(4-bromo-1-methyl-2-(methylthio)-1H-imidazol-5-yl)-1-propenyl)-5-methyl-, (E)-
CAS No.:138336-01-3
Molecular Formula:C₁₃H₁₅BrN₄S
Molecular Weight:339.259
Hs Code.:

Synonyms:138336-01-3;Pyrazine, 2-(2-(4-bromo-1-methyl-2-(methylthio)-1H-imidazol-5-yl)-1-propenyl)-5-methyl-, (E)-

Suppliers and Price of Pyrazine, 2-(2-(4-bromo-1-methyl-2-(methylthio)-1H-imidazol-5-yl)-1-propenyl)-5-methyl-, (E)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrazine, 2-(2-(4-bromo-1-methyl-2-(methylthio)-1H-imidazol-5-yl)-1-propenyl)-5-methyl-, (E)-

Chemical Property:

Vapor Pressure:1.68E-08mmHg at 25°C
Boiling Point:456°Cat760mmHg
Flash Point:229.6°C
Density:1.45g/cm³
XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:338.02008
Heavy Atom Count:19
Complexity:339

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CN=C(C=N1)C=C(C)C2=C(N=C(N2C)SC)Br
Isomeric SMILES:CC1=CN=C(C=N1)/C=C(\C)/C2=C(N=C(N2C)SC)Br

Technology Process of Pyrazine, 2-(2-(4-bromo-1-methyl-2-(methylthio)-1H-imidazol-5-yl)-1-propenyl)-5-methyl-, (E)-

There total 5 articles about Pyrazine, 2-(2-(4-bromo-1-methyl-2-(methylthio)-1H-imidazol-5-yl)-1-propenyl)-5-methyl-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108905-63-1
Methyl 4-bromo-1-methyl-2-methylthio-5-imidazolecarboxylate

: 138336-01-3
(E)-1-(5-methyl-2-pyrazinyl)-2-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)prop-1-ene

Guidance literature:: Multi-step reaction with 4 steps

1: 1) LDA, 2) LiOMe / 1) THF, -78 deg C, 1 h, 2) THF, -5 deg C

2: 99 percent / trifluoroacetic acid / 24 h / Heating

3: 1) LDA / 1) THF, hexanes, -78 deg C, 2) THF, -20 to -15 deg C

4: p-TsOH*H₂O / toluene / 0.17 h / Heating

With lithium methanolate; toluene-4-sulfonic acid; trifluoroacetic acid; lithium diisopropyl amide; In toluene;
DOI:10.1021/jo00031a017

Reference yield:

: 123-32-0
2,5-dimethyl-pyrazine

: 138336-01-3
(E)-1-(5-methyl-2-pyrazinyl)-2-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)prop-1-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 1) LDA / 1) THF, hexanes, -78 deg C, 2) THF, -20 to -15 deg C

2: p-TsOH*H₂O / toluene / 0.17 h / Heating

With toluene-4-sulfonic acid; lithium diisopropyl amide; In toluene;
DOI:10.1021/jo00031a017

Reference yield:

: 138335-97-4
1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)ethanone

: 138336-01-3
(E)-1-(5-methyl-2-pyrazinyl)-2-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)prop-1-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 1) LDA / 1) THF, hexanes, -78 deg C, 2) THF, -20 to -15 deg C

2: p-TsOH*H₂O / toluene / 0.17 h / Heating

With toluene-4-sulfonic acid; lithium diisopropyl amide; In toluene;
DOI:10.1021/jo00031a017