2-(4-BroMo-3-Methyl-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol

Base Information

Chemical Name:2-(4-BroMo-3-Methyl-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol
CAS No.:604799-57-7
Molecular Formula:C₁₀H₇BrF₆O
Molecular Weight:337.059
Hs Code.:
Mol file:604799-57-7.mol

Synonyms:2-(4-bromo-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Suppliers and Price of 2-(4-BroMo-3-Methyl-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-(4-BroMo-3-Methyl-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of 2-(4-BroMo-3-Methyl-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol

There total 3 articles about 2-(4-BroMo-3-Methyl-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₉H₆BrF₃O

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 604799-57-7
2-(4-bromo-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 2h; Cooling with ice;

Reference yield:

: 615-59-8
1,4-dibromo-2-methylbenzene

: 684-16-2
Hexafluoroacetone

: 604799-58-8
2-(4-bromo-2-methyl-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol

: 604799-57-7
2-(4-bromo-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Guidance literature:: 1,4-dibromo-2-methylbenzene; With n-butyllithium; In diethyl ether; at -78 ℃; for 0.5h;

Hexafluoroacetone; In tetrahydrofuran; at -50 ℃; for 2h;
DOI:10.1016/S0960-894X(02)00615-7

Reference yield:

: 148547-19-7
4-Bromo-3-methylbenzoic acid methyl ester

: 604799-57-7
2-(4-bromo-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / -15 °C

1.2: 0.25 h / 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C / Cooling with ice

With tetrabutyl ammonium fluoride; In tetrahydrofuran;