dimethyl-5,5 dimethylamino-2 thioxo-4 aza-3 hexene-2 dioate de ⁽¹⁾-ethyle et de ⁽⁶⁾-p-methoxybenzyle

Base Information

• Chemical Name: dimethyl-5,5 dimethylamino-2 thioxo-4 aza-3 hexene-2 dioate de ⁽¹⁾-ethyle et de ⁽⁶⁾-p-methoxybenzyle
• CAS No.: 115823-85-3
• Molecular Formula: C₁₉H₂₆N₂O₅S
• Molecular Weight: 394.492
• Mol file: 115823-85-3.mol

Synonyms:dimethyl-5,5 dimethylamino-2 thioxo-4 aza-3 hexene-2 dioate de ⁽¹⁾-ethyle et de ⁽⁶⁾-p-methoxybenzyle

Chemical Property of dimethyl-5,5 dimethylamino-2 thioxo-4 aza-3 hexene-2 dioate de ⁽¹⁾-ethyle et de ⁽⁶⁾-p-methoxybenzyle

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl-5,5 dimethylamino-2 thioxo-4 aza-3 hexene-2 dioate de ⁽¹⁾-ethyle et de ⁽⁶⁾-p-methoxybenzyle

There total 2 articles about dimethyl-5,5 dimethylamino-2 thioxo-4 aza-3 hexene-2 dioate de ⁽¹⁾-ethyle et de ⁽⁶⁾-p-methoxybenzyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

ethyl 2-(dimethylamino)-2,2-diethoxyacetate (34644-30-9) + methyl-2 thiocarbamoyl-2 propanoate de p-methoxybenzyle (115823-83-1) → dimethyl-5,5 dimethylamino-2 thioxo-4 aza-3 hexene-2 dioate de (1)-ethyle et de (6)-p-methoxybenzyle (115823-85-3)

Guidance literature:

In chloroform; for 24h; Heating;

DOI:10.1016/S0040-4020(01)85890-7

Reference yield:

cyano-2 methyl propanoate de p-methoxybenzyle (115849-39-3) → dimethyl-5,5 dimethylamino-2 thioxo-4 aza-3 hexene-2 dioate de (1)-ethyle et de (6)-p-methoxybenzyle (115823-85-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / 1.) H₂S; 2.) Et₃N / pyridine / 24 h

2: 74 percent / CHCl₃ / 24 h / Heating

With hydrogen sulfide; triethylamine; In pyridine; chloroform;

DOI:10.1016/S0040-4020(01)85890-7

Reference yield: 87.0%

dimethyl-5,5 dimethylamino-2 thioxo-4 aza-3 hexene-2 dioate de (1)-ethyle et de (6)-p-methoxybenzyle (115823-85-3) + acrolein (107-02-8,25068-14-8) → (ethoxycarbonyl-4 formyl-5 6H-thiazine-1,3 yl-2)-2 methyl-2 propanoate de p-methoxybenzyle (115823-87-5)

Guidance literature:

With Amberlyst 15; In dichloromethane; for 20h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85890-7

upstream raw materials:

ethyl 2-(dimethylamino)-2,2-diethoxyacetate

methyl-2 thiocarbamoyl-2 propanoate de p-methoxybenzyle

cyano-2 methyl propanoate de p-methoxybenzyle

Downstream raw materials:

(ethoxycarbonyl-4 formyl-5 6H-thiazine-1,3 yl-2)-2 methyl-2 propanoate de p-methoxybenzyle

(ethoxycarbonyl-4 methoxycarbonyl-5 dihydro-3,6 2H-thiazine-1,3 yl-2)-2 methyl-2 propanoate de p-methoxybenzyle

(ethoxycarbonyl-4 methoxycarbonyl-5 6H-thiazine-1,3 yl-2)-2 methyl-2 propanoate de p-methoxybenzyle