2-(2-bromo-4,5-dimethoxyphenyl)-1-{(2R)-2-[2-(4-methoxyphenyl)-2-oxoethyl]piperidin-1-yl}ethanone

Base Information

Chemical Name:2-(2-bromo-4,5-dimethoxyphenyl)-1-{(2R)-2-[2-(4-methoxyphenyl)-2-oxoethyl]piperidin-1-yl}ethanone
CAS No.:1227366-14-4
Molecular Formula:C₂₄H₂₈BrNO₅
Molecular Weight:490.394
Hs Code.:

Synonyms:2-(2-bromo-4,5-dimethoxyphenyl)-1-{(2R)-2-[2-(4-methoxyphenyl)-2-oxoethyl]piperidin-1-yl}ethanone

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Chemical Property of 2-(2-bromo-4,5-dimethoxyphenyl)-1-{(2R)-2-[2-(4-methoxyphenyl)-2-oxoethyl]piperidin-1-yl}ethanone

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Technology Process of 2-(2-bromo-4,5-dimethoxyphenyl)-1-{(2R)-2-[2-(4-methoxyphenyl)-2-oxoethyl]piperidin-1-yl}ethanone

There total 4 articles about 2-(2-bromo-4,5-dimethoxyphenyl)-1-{(2R)-2-[2-(4-methoxyphenyl)-2-oxoethyl]piperidin-1-yl}ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1227366-28-0
2-(2-bromo-4,5-dimethoxyphenyl)-1-{(2R)-2-[2-hydroxy-2-(4-methoxyphenyl)ethyl]piperidin-1-yl}ethanone

: 1227366-14-4
2-(2-bromo-4,5-dimethoxyphenyl)-1-{(2R)-2-[2-(4-methoxyphenyl)-2-oxoethyl]piperidin-1-yl}ethanone

Guidance literature:: With dipyridinium dichromate; silica gel; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1002/ejoc.200901404

Reference yield:

: 4697-62-5
6-bromohomoveratric acid

: 1-(4-methoxyphenyl)-2-(piperidin-2-yl)ethanone hydrochloride

: 1227366-14-4
2-(2-bromo-4,5-dimethoxyphenyl)-1-{(2R)-2-[2-(4-methoxyphenyl)-2-oxoethyl]piperidin-1-yl}ethanone

Guidance literature:: 6-bromohomoveratric acid; With N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

1-(4-methoxyphenyl)-2-(piperidin-2-yl)ethanone hydrochloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.ejmech.2015.01.038

Reference yield:

: 1-(4-methoxyphenyl)-2-(1-tert-butoxycarbonylpiperidin-2-yl)ethanone

: 1227366-14-4
2-(2-bromo-4,5-dimethoxyphenyl)-1-{(2R)-2-[2-(4-methoxyphenyl)-2-oxoethyl]piperidin-1-yl}ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; chloro-trimethyl-silane / 0 - 20 °C / Inert atmosphere

2.1: O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 1 h / 0 - 20 °C / Inert atmosphere

With methanol; chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2015.01.038