(4E,8E)-2-Amino-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide

Base Information

Chemical Name:(4E,8E)-2-Amino-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide
CAS No.:638132-17-9
Molecular Formula:C₂₄H₃₆N₂O
Molecular Weight:368.563
Hs Code.:

Synonyms:(4E,8E)-2-Amino-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4E,8E)-2-Amino-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide

Chemical Property:

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Technology Process of (4E,8E)-2-Amino-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide

There total 6 articles about (4E,8E)-2-Amino-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 638132-16-8
((3E,7E)-1-Benzylcarbamoyl-4,8,12-trimethyl-trideca-3,7,11-trienyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

: 638132-17-9
(4E,8E)-2-Amino-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide

Guidance literature:: With piperidine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0960-894X(03)00171-9

Reference yield:

: 24163-93-7,24163-94-8,56881-57-3,6874-67-5,28290-41-7
farnesyl bromide

: 638132-17-9
(4E,8E)-2-Amino-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide

Guidance literature:: Multi-step reaction with 6 steps

1: LDA / tetrahydrofuran / -78 - 20 °C

2: 2 N aq. HCl

3: 84 percent / aq. LiOH / tetrahydrofuran / 20 °C

4: 94 percent / aq. Na₂CO₃ / dioxane / 0 - 20 °C

5: 82 percent / EDC; HOOBT; DIEA / CH₂Cl₂ / 20 °C

6: 93 percent / piperidine / dimethylformamide / 20 °C

With piperidine; hydrogenchloride; lithium hydroxide; sodium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00171-9

Reference yield:

: 638132-18-0
(4E,8E)-2-Amino-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid

: 638132-17-9
(4E,8E)-2-Amino-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / aq. Na₂CO₃ / dioxane / 0 - 20 °C

2: 82 percent / EDC; HOOBT; DIEA / CH₂Cl₂ / 20 °C

3: 93 percent / piperidine / dimethylformamide / 20 °C

With piperidine; sodium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00171-9