(4E,8E)-2-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide

Base Information

Chemical Name:(4E,8E)-2-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide
CAS No.:565469-61-6
Molecular Formula:C₃₆H₄₅N₅O
Molecular Weight:563.786
Hs Code.:

Synonyms:(4E,8E)-2-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide

Suppliers and Price of (4E,8E)-2-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4E,8E)-2-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4E,8E)-2-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide

There total 6 articles about (4E,8E)-2-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 183500-37-0
4-[(5-formyl-1H-imidazol-1-yl)methyl]benzonitrile

: 638132-17-9
(4E,8E)-2-Amino-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide

: 565469-61-6
(4E,8E)-2-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃;
DOI:10.1016/S0960-894X(03)00171-9

Reference yield:

: 638132-18-0
(4E,8E)-2-Amino-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid

: 565469-61-6
(4E,8E)-2-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / aq. Na₂CO₃ / dioxane / 0 - 20 °C

2: 82 percent / EDC; HOOBT; DIEA / CH₂Cl₂ / 20 °C

3: 93 percent / piperidine / dimethylformamide / 20 °C

4: 46 percent / AcOH; NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

With piperidine; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00171-9

Reference yield:

: 870526-97-9
(4E,8E)-2-(Benzhydrylidene-amino)-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid ethyl ester

: 565469-61-6
(4E,8E)-2-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide

Guidance literature:: Multi-step reaction with 6 steps

1: 2 N aq. HCl

2: 84 percent / aq. LiOH / tetrahydrofuran / 20 °C

3: 94 percent / aq. Na₂CO₃ / dioxane / 0 - 20 °C

4: 82 percent / EDC; HOOBT; DIEA / CH₂Cl₂ / 20 °C

5: 93 percent / piperidine / dimethylformamide / 20 °C

6: 46 percent / AcOH; NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

With piperidine; hydrogenchloride; lithium hydroxide; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00171-9