6-(4-cyclopropylpiperazin-1-yl)-2-(4-fluorophenyl)-3-pyridazin-4-yl-imidazo[1,2-b]pyridazine

Base Information

Chemical Name:6-(4-cyclopropylpiperazin-1-yl)-2-(4-fluorophenyl)-3-pyridazin-4-yl-imidazo[1,2-b]pyridazine
CAS No.:1105714-24-6
Molecular Formula:C₂₃H₂₂FN₇
Molecular Weight:415.473
Hs Code.:

Synonyms:6-(4-cyclopropylpiperazin-1-yl)-2-(4-fluorophenyl)-3-pyridazin-4-yl-imidazo[1,2-b]pyridazine

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Chemical Property of 6-(4-cyclopropylpiperazin-1-yl)-2-(4-fluorophenyl)-3-pyridazin-4-yl-imidazo[1,2-b]pyridazine

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Technology Process of 6-(4-cyclopropylpiperazin-1-yl)-2-(4-fluorophenyl)-3-pyridazin-4-yl-imidazo[1,2-b]pyridazine

There total 7 articles about 6-(4-cyclopropylpiperazin-1-yl)-2-(4-fluorophenyl)-3-pyridazin-4-yl-imidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27374-25-0
[(1-Ethoxycyclopropyl)oxy]trimethylsilane

: 1105714-07-5
2-(4-fluorophenyl)-6-piperazin-1-yl-3-pyridazin-4-yl-imidazo[1,2-b]pyridazine

: 1105714-24-6
6-(4-cyclopropylpiperazin-1-yl)-2-(4-fluorophenyl)-3-pyridazin-4-yl-imidazo[1,2-b]pyridazine

Guidance literature:: With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; at 50 ℃; for 2.25h;

Reference yield:

: 1120-88-3
4-methylpyridazine

: 1105714-24-6
6-(4-cyclopropylpiperazin-1-yl)-2-(4-fluorophenyl)-3-pyridazin-4-yl-imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: bromine; sodium acetate / acetic acid / 20 °C

3: diethyl ether; butan-1-ol / 1 h / Reflux

4: ammonium formate / palladium 10% on activated carbon / methanol / 0.25 h / Reflux

5: sodium cyanoborohydride; acetic acid / tetrahydrofuran; methanol / 2.25 h / 50 °C

With bromine; ammonium formate; sodium acetate; sodium hexamethyldisilazane; sodium cyanoborohydride; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; acetic acid; butan-1-ol;

Reference yield:

: 451-46-7
4-fluorobenzoic acid ethyl ester

: 1105714-24-6
6-(4-cyclopropylpiperazin-1-yl)-2-(4-fluorophenyl)-3-pyridazin-4-yl-imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: bromine; sodium acetate / acetic acid / 20 °C

3: diethyl ether; butan-1-ol / 1 h / Reflux

4: ammonium formate / palladium 10% on activated carbon / methanol / 0.25 h / Reflux

5: sodium cyanoborohydride; acetic acid / tetrahydrofuran; methanol / 2.25 h / 50 °C

With bromine; ammonium formate; sodium acetate; sodium hexamethyldisilazane; sodium cyanoborohydride; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; acetic acid; butan-1-ol;