4-Methylpyridazine

Base Information

• Chemical Name: 4-Methylpyridazine
• CAS No.: 1120-88-3
• Molecular Formula: C5H6N2
• Molecular Weight: 94.116
• Hs Code.: 29339900
• Mol file: 1120-88-3.mol

Synonyms:Pyridazine, 4-methyl-;4-Methyl pyridazine;

Chemical Property of 4-Methylpyridazine

Chemical Property:

• Appearance/Colour: Clear yellow liquid
• Vapor Pressure: 0.12mmHg at 25°C
• Refractive Index: n20/D 1.521(lit.)
• Boiling Point: 226.9 °C at 760 mmHg
• PKA: 3.74±0.10(Predicted)
• Flash Point: 105.6 °C
• PSA: 25.78000
• Density: 1.021 g/cm³
• LogP: 0.78500
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Methylpyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-Methylpyridazine was used in the preparation of series of novel pyridazine derivatives structurally related to bipyridine cardiotonics.

Technology Process of 4-Methylpyridazine

There total 17 articles about 4-Methylpyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ 4-methylpyridazine (1120-88-3)

Guidance literature:

Reference yield: 50.0%

1,2-diazine (289-80-5) + acetic acid (64-19-7,77671-22-8) → 4-methylpyridazine (1120-88-3) + 3,5-dimethyl-pyridazine (22863-58-7) + 3,4-dimethylpyridazine (68206-10-0) + 4,5-dimethylpyridazine (38283-35-1) + 3,4,5,6-tetramethylpyridazine (22868-72-0) + 3,4,5-trimethyl-pyridazine (22863-59-8)

Guidance literature:

With ammonium peroxydisulfate; silver nitrate; In sulfuric acid; at 90 ℃; for 1h; Product distribution; other 1,2-diazines, other source of methyl radical;

Reference yield: 33.0%

1,2-diazine (289-80-5) + tert.-butylhydroperoxide (75-91-2) → 4-methylpyridazine (1120-88-3) + 3,5-dimethyl-pyridazine (22863-58-7) + 4,5-dimethylpyridazine (38283-35-1) + 3,4,5-trimethyl-pyridazine (22863-59-8)

Guidance literature:

With iron(II) sulfate; In sulfuric acid; at 25 ℃; for 1h; Further byproducts given;

upstream raw materials:

3-chloro-5-methylpyridazine

3,6-dichloro-4-methylpyridazine

1,2-diazine

tert.-butylhydroperoxide

Downstream raw materials:

1-(4-methoxyphenyl)-2-(4-pyridazinyl)ethanol

4-ethylpyridazine

6-(4-benzylpiperazin-1-yl)-2-(4-fluorophenyl)-3-pyridazin-4-yl-imidazo[1,2-b]pyridazine

6-(4-cyclopropylpiperazin-1-yl)-2-(4-fluorophenyl)-3-pyridazin-4-yl-imidazo[1,2-b]pyridazine

Refernces

• 1、 Suzuki, Masaaki,Sumi, Kengo,Koyama, Hiroko,Siqin,Hosoya, Takamitsu,Takashima-Hirano, Misato,Doi, Hisashi. "Pd0-mediated rapid coupling between methyl iodide and heteroarylstannanes: an efficient and general method for the incorporation of a positron-emitting11C radionuclide into heteroaromatic frameworks". experimental part. p. 12489 - 12495. Retrieved 2010/06/11.
• 2、 Tsuchiya,Arai,Igeta. "Photochemistry. IX. Formation of cyclopropenyl ketones and furans from pyridazine N oxides by irradiation". . p. 2747 - 2751. Retrieved 2007/10/04.