(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)(3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)phenyl)ketone

Base Information

Chemical Name:(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)(3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)phenyl)ketone
CAS No.:1035198-64-1
Molecular Formula:C₁₇H₂₂N₂O₆S
Molecular Weight:382.437
Hs Code.:

Synonyms:(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)(3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)phenyl)ketone

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Chemical Property of (5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)(3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)phenyl)ketone

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Technology Process of (5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)(3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)phenyl)ketone

There total 6 articles about (5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)(3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)phenyl)ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoic acid

: 1035198-64-1
(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)(3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)phenyl)ketone

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / chloroform / 3 h / 20 °C

2: triethylamine / tetrahydrofuran / 5 h / Reflux

3: triethylamine; 2-hydroxy-2-methylpropanenitrile / acetonitrile / 18 h / 20 °C / Cooling with ice

With oxalyl dichloride; triethylamine; 2-hydroxy-2-methylpropanenitrile; N,N-dimethyl-formamide; In tetrahydrofuran; chloroform; acetonitrile;

Reference yield:

: 118-69-4
2,6-dichlorotoluene

: 1035198-64-1
(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)(3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)phenyl)ketone

Guidance literature:: Multi-step reaction with 6 steps

1.1: 80 °C

1.2: 6 h / 80 - 120 °C

2.1: sodium hydroxide / toluene / 3 h / Reflux

3.1: water; sodium carbonate / 5%-palladium/activated carbon; 1,4-di(diphenylphosphino)-butane / tert-butyl alcohol / 7 h / 160 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / chloroform / 3 h / 20 °C

5.1: triethylamine / tetrahydrofuran / 5 h / Reflux

6.1: triethylamine; 2-hydroxy-2-methylpropanenitrile / acetonitrile / 18 h / 20 °C / Cooling with ice

With oxalyl dichloride; water; sodium carbonate; triethylamine; 2-hydroxy-2-methylpropanenitrile; sodium hydroxide; 5%-palladium/activated carbon; N,N-dimethyl-formamide; 1,4-di(diphenylphosphino)-butane; In tetrahydrofuran; chloroform; toluene; acetonitrile; tert-butyl alcohol;

Reference yield:

: 496805-63-1
2,6-dichloro-3-(methylsulfonyl)toluene

: 1035198-64-1
(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)(3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)phenyl)ketone

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / toluene / 3 h / Reflux

2: water; sodium carbonate / 5%-palladium/activated carbon; 1,4-di(diphenylphosphino)-butane / tert-butyl alcohol / 7 h / 160 °C

3: oxalyl dichloride / N,N-dimethyl-formamide / chloroform / 3 h / 20 °C

4: triethylamine / tetrahydrofuran / 5 h / Reflux

5: triethylamine; 2-hydroxy-2-methylpropanenitrile / acetonitrile / 18 h / 20 °C / Cooling with ice

With oxalyl dichloride; water; sodium carbonate; triethylamine; 2-hydroxy-2-methylpropanenitrile; sodium hydroxide; 5%-palladium/activated carbon; N,N-dimethyl-formamide; 1,4-di(diphenylphosphino)-butane; In tetrahydrofuran; chloroform; toluene; acetonitrile; tert-butyl alcohol;