Z-L-Pro-L-βClAla-OMe

Base Information

• Chemical Name: Z-L-Pro-L-βClAla-OMe
• CAS No.: 126749-77-7
• Molecular Formula: C₁₇H₂₁ClN₂O₅
• Molecular Weight: 368.817
• Mol file: 126749-77-7.mol

Synonyms:Z-L-Pro-L-βClAla-OMe

Chemical Property of Z-L-Pro-L-βClAla-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-L-Pro-L-βClAla-OMe

There total 1 articles about Z-L-Pro-L-βClAla-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

Methyl (2R)-2-amino-3-chloropropionate hydrochloride (17136-54-8) + N-Benzyloxycarbonyl-L-proline (1148-11-4) → Z-L-Pro-L-βClAla-OMe (126749-77-7)

Guidance literature:

With triethylamine; isobutyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide; at -15 ℃; for 3h;

DOI:10.1016/S0040-4020(01)89507-7

Reference yield: 97.0%

Z-L-Pro-L-βClAla-OMe (126749-77-7) → Z-L-Pro-ΔAla-OMe (126749-81-3)

Guidance literature:

With triethylamine; In ethyl acetate; Ambient temperature;

DOI:10.1016/S0040-4020(01)89507-7

Reference yield:

Z-L-Pro-L-βClAla-OMe (126749-77-7) → Z-L-Pro-DL-Leu-OMe (126749-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / triethylamine / ethyl acetate / Ambient temperature

2: 98 percent / sodium borohydride / H₂O; CH₂Cl₂ / 1 h / Ambient temperature

With sodium tetrahydroborate; triethylamine; In dichloromethane; water; ethyl acetate;

DOI:10.1016/S0040-4020(01)89507-7

upstream raw materials:

Methyl (2R)-2-amino-3-chloropropionate hydrochloride

N-Benzyloxycarbonyl-L-proline

Downstream raw materials:

Z-L-Pro-ΔAla-OMe

Z-L-Pro-DL-Leu-OMe