17136-54-8

Basic information

• Product Name: BETA-CHLORO-D-ALANINE HYDROCHLORIDE
• Synonyms: BETA-CHLORO-L-ALANINE METHYL ESTER HYDROCHLORIDE;BETA-CHLORO-D-ALANINE HYDROCHLORIDE;BETA-CHLORO-ALANINE-OME HCL;BETA-CHLORO-D-ALANINE HCL;H-D-BETA-CHLORO-ALA-OH HCL;H-D-ALA(3-CL)-OH HCL;H-D-ALA(BETA-CL)-OH HCL;H-BETA-CHLORO-ALA-OME HCL
• CAS NO: 17136-54-8
• Molecular Formula: C₄H₉ClNO₂*Cl
• Molecular Weight: 174.03
• EINECS: 266-624-2
• Product Categories: Amino Acids & Derivatives
• Mol File: 17136-54-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 155-157°C
• Boiling Point: 164.4 °C at 760 mmHg
• Flash Point: 53.2 °C
• Appearance: /
• Density: 1.212 g/cm³
• Vapor Pressure: 0.201mmHg at 25°C
• Storage Temp.: −20°C
• Solubility: Dichloromethane (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• CAS DataBase Reference: BETA-CHLORO-D-ALANINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BETA-CHLORO-D-ALANINE HYDROCHLORIDE(17136-54-8)
• EPA Substance Registry System: BETA-CHLORO-D-ALANINE HYDROCHLORIDE(17136-54-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 17136-54-8(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

L-β-Chloroalanine Methyl Ester Hydrochloride (cas# 17136-54-8) is a compound useful in organic synthesis.

InChI:InChI=1/C4H8ClNO2.ClH/c1-8-4(7)3(6)2-5;/h3H,2,6H2,1H3;1H/t3-;/m0./s1

Upstream product

• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 
• 56-45-1 L-serin 
• 10026-13-8 phosphorus pentachloride 
• 5619-04-5 methyl 2-amino-3-hydroxypropanoate hydrochloride 
• 2104-89-4 Ser-OMe 
• 75-36-5 acetyl chloride 

Downstream Products

• 2731-73-9 2-amino-3-chloropropanoic acid 
• 126749-75-5 Z-L-Cys(Z)-L-βClAla-OMe 
• 651035-84-6 2-(R)-tert-butoxycarbonylamino-3-chloro-propionic acid methyl ester 
• 18635-38-6 (+)-2-acetamido-3-chloropropanoic acid methyl ester 
• 68-41-7 cycloserine 
• 339-72-0 L-cycloserine 
• 51887-89-9 β-chloro-L-alanine hydrochloride 
• 126749-77-7 Z-L-Pro-L-βClAla-OMe 
• 27748-58-9 ester methylique de la N-benzoyl β-chloro L-alanine 
• 62076-46-4 Z-L-Phe-L-βClAla-OMe 
• 62076-47-5 Z-L-Val-L-βClAla-OMe 

Relevant articles and documents

Method for synthesizing L -selenium - methylselenocysteine

The invention provides a method for synthesizing L -selenium - methylselenocysteine, and relates to the reaction of a compound of formula II or a salt thereof with dimethyl diselenoate, and the method comprises MBH. 4 The method comprises the following steps: directly synthesizing L - selenium - methylselenocysteine through a one-pot reaction under the action of alkali or synthesizing L - selenium - methylselenocysteine, and hydrolyzing to obtain L - selenium - methylselenocysteine. The synthesis method has the advantages of simple reaction. The method has the advantages of convenient operation, high product yield, good quality, low cost and suitability for industrialization.

N-acetyl-β-chloro-L-alanine methyl ester preparation method

The invention provides a method for preparing N-acetyl-beta-chlorine-L-alanine methyl ester. The method includes the steps that (a) serine serves as a starting material and is esterified through methanol or ethyl alcohol, (b) the esterified matter is chlorinated through sulfoxide chloride, (c) the chlorinated matter undergoes acylation, (d) the acylated matter is recrystallized, and accordingly the N-acetyl-beta-chlorine-L-alanine methyl ester is obtained. The method is high in reaction yield, by-products are few, reaction mother liquor is recycled and reused, distilled liquid obtained after acylation is acetic acid and acetic anhydride, and the liquid is recycled and reused after being purified. Accordingly, cost is low, tail gas generated in reactions is absorbed through strong-base solutions to form salt and then is separated and used, and accordingly environment protection is achieved.

Dual inhibition of human leukocyte elastase and lipid peroxidation: In vitro and in vivo activities of azabicyclo[2.2.2]octane and perhydroindole derivatives

A series of potent and selective human leukocyte elastase (HLE) inhibitors of the Val-Pro-Val type has been developed. Initially, the central proline residue was replaced by nonnatural amino acids Phi ((2S,3aS,7aS)- perhydroindole-2-carboxylic acid) and A