(3S,5R)-3-[(tert-butyldimethylsilyl)oxy]-5-[N-[[2-(tert-butyldimethylsilyl)oxyethyl]carbamoyl]oxy]-1-ethynyl-2-methylcyclohex-1-ene

Base Information

Chemical Name:(3S,5R)-3-[(tert-butyldimethylsilyl)oxy]-5-[N-[[2-(tert-butyldimethylsilyl)oxyethyl]carbamoyl]oxy]-1-ethynyl-2-methylcyclohex-1-ene
CAS No.:796039-26-4
Molecular Formula:C₂₄H₄₅NO₄Si₂
Molecular Weight:467.797
Hs Code.:

Synonyms:(3S,5R)-3-[(tert-butyldimethylsilyl)oxy]-5-[N-[[2-(tert-butyldimethylsilyl)oxyethyl]carbamoyl]oxy]-1-ethynyl-2-methylcyclohex-1-ene

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Chemical Property of (3S,5R)-3-[(tert-butyldimethylsilyl)oxy]-5-[N-[[2-(tert-butyldimethylsilyl)oxyethyl]carbamoyl]oxy]-1-ethynyl-2-methylcyclohex-1-ene

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Technology Process of (3S,5R)-3-[(tert-butyldimethylsilyl)oxy]-5-[N-[[2-(tert-butyldimethylsilyl)oxyethyl]carbamoyl]oxy]-1-ethynyl-2-methylcyclohex-1-ene

There total 1 articles about (3S,5R)-3-[(tert-butyldimethylsilyl)oxy]-5-[N-[[2-(tert-butyldimethylsilyl)oxyethyl]carbamoyl]oxy]-1-ethynyl-2-methylcyclohex-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 190264-76-7
(2-Hydroxy-ethyl)-carbamic acid (1R,5S)-3-ethynyl-5-hydroxy-4-methyl-cyclohex-3-enyl ester

: 796039-26-4
(3S,5R)-3-[(tert-butyldimethylsilyl)oxy]-5-[N-[[2-(tert-butyldimethylsilyl)oxyethyl]carbamoyl]oxy]-1-ethynyl-2-methylcyclohex-1-ene

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2004.07.042

Reference yield:

: 222317-53-5
25-trimethylsilyloxy-de-A,B-cholest-8-en-8-yl trifluoromethanesulfonate

: 796039-26-4
(3S,5R)-3-[(tert-butyldimethylsilyl)oxy]-5-[N-[[2-(tert-butyldimethylsilyl)oxyethyl]carbamoyl]oxy]-1-ethynyl-2-methylcyclohex-1-ene

: [2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-carbamic acid 5-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-ylethynyl]-4-methyl-cyclohex-3-enyl ester

Guidance literature:: With copper(l) iodide; diethylamine; bis(triphenylphosphine) palladium (Il) acetate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2004.07.042

Reference yield:

: 796039-26-4
(3S,5R)-3-[(tert-butyldimethylsilyl)oxy]-5-[N-[[2-(tert-butyldimethylsilyl)oxyethyl]carbamoyl]oxy]-1-ethynyl-2-methylcyclohex-1-ene

: 796039-30-0
6,7-dehydro-3-O-[N-(2-hydroxyethyl)carbamoyl]-1α,25-dihydroxyvitamin D3

Guidance literature:: Multi-step reaction with 2 steps

1: CuI; Et₂NH / Pd(PPh₃)2(OAc)2 / dimethylformamide / 1 h / 20 °C

2: TBAF / tetrahydrofuran / 12 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; diethylamine; bis(triphenylphosphine) palladium (Il) acetate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.07.042