DL-2-[4-chloro-6-(4-sulfamoylbenzylamino)-1,3,5-triazin-2-ylamino]-3-(3,4-dihydroxyphenyl)propanoic acid

Base Information

Chemical Name:DL-2-[4-chloro-6-(4-sulfamoylbenzylamino)-1,3,5-triazin-2-ylamino]-3-(3,4-dihydroxyphenyl)propanoic acid
CAS No.:1311200-31-3
Molecular Formula:C₁₉H₁₉ClN₆O₆S
Molecular Weight:494.915
Hs Code.:

Synonyms:DL-2-[4-chloro-6-(4-sulfamoylbenzylamino)-1,3,5-triazin-2-ylamino]-3-(3,4-dihydroxyphenyl)propanoic acid

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Chemical Property of DL-2-[4-chloro-6-(4-sulfamoylbenzylamino)-1,3,5-triazin-2-ylamino]-3-(3,4-dihydroxyphenyl)propanoic acid

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Technology Process of DL-2-[4-chloro-6-(4-sulfamoylbenzylamino)-1,3,5-triazin-2-ylamino]-3-(3,4-dihydroxyphenyl)propanoic acid

There total 2 articles about DL-2-[4-chloro-6-(4-sulfamoylbenzylamino)-1,3,5-triazin-2-ylamino]-3-(3,4-dihydroxyphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 63-84-3,90638-38-3
dopa

: 796871-26-6
4-{[(4,6-dichloro-1,3,5-triazin-2-yl)amino]methyl}-benzene-1-sulfonamide

: 1311200-31-3
DL-2-[4-chloro-6-(4-sulfamoylbenzylamino)-1,3,5-triazin-2-ylamino]-3-(3,4-dihydroxyphenyl)propanoic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2011.04.005

Reference yield:

: 138-37-4
mafenide hydrochloride

: 1311200-31-3
DL-2-[4-chloro-6-(4-sulfamoylbenzylamino)-1,3,5-triazin-2-ylamino]-3-(3,4-dihydroxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetone / 0 °C

1.2: 1.33 h

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmc.2011.04.005