2-(3-tert-butyl-isoxazol-5-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:2-(3-tert-butyl-isoxazol-5-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine
CAS No.:1332875-09-8
Molecular Formula:C₂₀H₁₆ClF₃N₄O
Molecular Weight:420.821
Hs Code.:

Synonyms:2-(3-tert-butyl-isoxazol-5-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

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Chemical Property of 2-(3-tert-butyl-isoxazol-5-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

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Technology Process of 2-(3-tert-butyl-isoxazol-5-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

There total 9 articles about 2-(3-tert-butyl-isoxazol-5-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332875-11-2
3-tert-butyl-isoxazole-5-carboxylic acid [3-amino-4-chloro-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide

: 1332875-09-8
2-(3-tert-butyl-isoxazol-5-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

Guidance literature:: 3-tert-butyl-isoxazole-5-carboxylic acid [3-amino-4-chloro-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide; (1S)-10-camphorsulfonic acid; In 1,4-dioxane; at 100 ℃; for 5h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 133674-40-5
3-tert-butylisoxazole-5-carboxylic acid

: 1332875-09-8
2-(3-tert-butyl-isoxazol-5-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

2: tetrahydrofuran; mineral oil / 0.25 h / 20 °C

3: ammonium chloride; iron / ethanol; water / 3 h / 50 °C

4: (1S)-10-camphorsulfonic acid / 1,4-dioxane / 5 h / 100 °C

With oxalyl dichloride; iron; ammonium chloride; N,N-dimethyl-formamide; (1S)-10-camphorsulfonic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; mineral oil;

Reference yield:

: 1332875-10-1
3-tert-butyl-isoxazole-5-carboxylic acid [4-chloro-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide

: 1332875-09-8
2-(3-tert-butyl-isoxazol-5-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium chloride; iron / ethanol; water / 3 h / 50 °C

2: (1S)-10-camphorsulfonic acid / 1,4-dioxane / 5 h / 100 °C

With iron; ammonium chloride; (1S)-10-camphorsulfonic acid; In 1,4-dioxane; ethanol; water;