N-(3-{6-[3-amino-4-(morpholine-4-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide

Base Information

• Chemical Name: N-(3-{6-[3-amino-4-(morpholine-4-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide
• CAS No.: 910233-94-2
• Molecular Formula: C₃₄H₃₈N₆O₄
• Molecular Weight: 594.714
• Mol file: 910233-94-2.mol

Synonyms:N-(3-{6-[3-amino-4-(morpholine-4-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide

Chemical Property of N-(3-{6-[3-amino-4-(morpholine-4-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-{6-[3-amino-4-(morpholine-4-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide

There total 8 articles about N-(3-{6-[3-amino-4-(morpholine-4-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(tert-butyl)-N-(2-methyl-3-(1-methyl-5-((4-(morpholine-4-carbonyl)-3-nitrophenyl)amino)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)benzamide (910234-22-9) → N-(3-{6-[3-amino-4-(morpholine-4-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide (910233-94-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2017.03.001

Reference yield:

N-(3-bromo-2-methylphenyl)-4-(tert-butyl)benzamide (1013116-83-0) → N-(3-{6-[3-amino-4-(morpholine-4-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide (910233-94-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 8 h / 100 °C / Inert atmosphere

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 110 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium acetate; sodium carbonate; In 1,4-dioxane; methanol; water; 1: |Suzuki Coupling / 2: |Suzuki Coupling;

DOI:10.1016/j.ejmech.2017.03.001

Reference yield:

5-bromo-1-methyl-3-((4-(morpholine-4-carbonyl)-3-nitrophenyl)amino)pyridin-2(1H)-one → N-(3-{6-[3-amino-4-(morpholine-4-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide (910233-94-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 110 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; In 1,4-dioxane; methanol; water; 1: |Suzuki Coupling;

DOI:10.1016/j.ejmech.2017.03.001

upstream raw materials:

4-(1,1-dimethylethyl)benzoic acid

p-tert-butyl benzoyl chloride

N-(3-bromo-2-methylphenyl)-4-(tert-butyl)benzamide

4-tert-butyl-N-[2-methyl-3-(4,4,5,5-tetramethyl-[1,2,3]dioxaborolan-2-yl)-phenyl]-benzamide