trans-3-(4-chloro-2-methyl-2(E)-butenyl)-4-isopropyl-1-methylcyclohex-1-ene

Base Information

• Chemical Name: trans-3-(4-chloro-2-methyl-2(E)-butenyl)-4-isopropyl-1-methylcyclohex-1-ene
• CAS No.: 122305-05-9
• Molecular Formula: C₁₅H₂₅Cl
• Molecular Weight: 240.816
• Mol file: 122305-05-9.mol

Synonyms:trans-3-(4-chloro-2-methyl-2(E)-butenyl)-4-isopropyl-1-methylcyclohex-1-ene

Chemical Property of trans-3-(4-chloro-2-methyl-2(E)-butenyl)-4-isopropyl-1-methylcyclohex-1-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-3-(4-chloro-2-methyl-2(E)-butenyl)-4-isopropyl-1-methylcyclohex-1-ene

There total 1 articles about trans-3-(4-chloro-2-methyl-2(E)-butenyl)-4-isopropyl-1-methylcyclohex-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(+/-)-3-Chloro-p-menthen (28582-40-3) + 3-Chloro-6-isopropyl-3-methyl-cyclohexene (111806-71-4) + isoprene (78-79-5,9003-31-0) → trans-3-(4-chloro-2-methyl-2(E)-butenyl)-4-isopropyl-1-methylcyclohex-1-ene (122305-05-9)

Guidance literature:

zinc chloride diethyl ether; In dichloromethane; at -78 ℃; for 1h;

DOI:10.1016/S0040-4020(01)89792-1

Reference yield:

trans-3-(4-chloro-2-methyl-2(E)-butenyl)-4-isopropyl-1-methylcyclohex-1-ene (122305-05-9) → rac β-muurolene (523-47-7,5951-61-1,6013-64-5,16509-53-8,122332-53-0,132296-09-4,5743-03-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / ZnCl₂*Et₂O / CH₂Cl₂ / 25 h / -78 °C

2: 44 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 50 h / Heating

With potassium tert-butylate; zinc chloride diethyl ether; In dichloromethane; tert-butyl alcohol;

DOI:10.1016/S0040-4020(01)89792-1

Reference yield:

trans-3-(4-chloro-2-methyl-2(E)-butenyl)-4-isopropyl-1-methylcyclohex-1-ene (122305-05-9) → rac γ2-muurolene (5957-56-2,7089-89-6,29336-47-8,82166-09-4,122332-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / ZnCl₂*Et₂O / CH₂Cl₂ / 25 h / -78 °C

2: 39 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 50 h / Heating

With potassium tert-butylate; zinc chloride diethyl ether; In dichloromethane; tert-butyl alcohol;

DOI:10.1016/S0040-4020(01)89792-1

upstream raw materials:

(+/-)-3-Chloro-p-menthen

3-Chloro-6-isopropyl-3-methyl-cyclohexene

isoprene

Downstream raw materials:

rac β-muurolene

rac γ₂-muurolene