(1S,2S)-6-(2-Chloro-benzyloxy)-2-isopropylamino-1,2,3,4-tetrahydro-naphthalen-1-ol; hydrochloride

Base Information

Chemical Name:(1S,2S)-6-(2-Chloro-benzyloxy)-2-isopropylamino-1,2,3,4-tetrahydro-naphthalen-1-ol; hydrochloride
CAS No.:88627-69-4
Molecular Formula:C₂₀H₂₄ClNO₂*ClH
Molecular Weight:382.33
Hs Code.:

Synonyms:(1S,2S)-6-(2-Chloro-benzyloxy)-2-isopropylamino-1,2,3,4-tetrahydro-naphthalen-1-ol; hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S)-6-(2-Chloro-benzyloxy)-2-isopropylamino-1,2,3,4-tetrahydro-naphthalen-1-ol; hydrochloride

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Technology Process of (1S,2S)-6-(2-Chloro-benzyloxy)-2-isopropylamino-1,2,3,4-tetrahydro-naphthalen-1-ol; hydrochloride

There total 2 articles about (1S,2S)-6-(2-Chloro-benzyloxy)-2-isopropylamino-1,2,3,4-tetrahydro-naphthalen-1-ol; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 66362-33-2,88628-28-8
(1S,2S)-2-Amino-6-(2-chloro-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-1-ol; hydrochloride

: 67-64-1
acetone

: 88627-69-4
(1S,2S)-6-(2-Chloro-benzyloxy)-2-isopropylamino-1,2,3,4-tetrahydro-naphthalen-1-ol; hydrochloride

Guidance literature:: With hydrogenchloride; ethanol; sodium cyanoborohydride; In methanol; at 5 ℃;
DOI:10.1248/cpb.31.2329

Reference yield:

: 66362-19-4
2-Amino-6-(2-chloro-benzyloxy)-3,4-dihydro-2H-naphthalen-1-one; hydrochloride

: 88627-69-4
(1S,2S)-6-(2-Chloro-benzyloxy)-2-isopropylamino-1,2,3,4-tetrahydro-naphthalen-1-ol; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / 1.) NaBH₄; 2.) 20percent HCl/EtOH / methanol / 0.5 h / Ambient temperature

2: 93 percent / 1.) NaBH₃CN; 2.) HCl/EtOH / methanol / 5 °C

With hydrogenchloride; sodium tetrahydroborate; ethanol; sodium cyanoborohydride; In methanol;
DOI:10.1248/cpb.31.2329