E,Z-3,4-bis(3,4,5-trimethoxyphenyl)-1-<2-(4-methoxyphenyl)ethyl>pyrrole-2,5-biscarboxamide

Base Information

Chemical Name:E,Z-3,4-bis(3,4,5-trimethoxyphenyl)-1-<2-(4-methoxyphenyl)ethyl>pyrrole-2,5-biscarboxamide
CAS No.:220231-09-4
Molecular Formula:C₅₁H₅₃N₃O₁₁
Molecular Weight:883.995
Hs Code.:

E,Z-3,4-bis(3,4,5-trimethoxyphenyl)-1-<2-(4-methoxyphenyl)ethyl>pyrrole-2,5-bis<N-2-(4-methoxystyryl)>carboxamide

Synonyms:E,Z-3,4-bis(3,4,5-trimethoxyphenyl)-1-<2-(4-methoxyphenyl)ethyl>pyrrole-2,5-biscarboxamide

Suppliers and Price of E,Z-3,4-bis(3,4,5-trimethoxyphenyl)-1-<2-(4-methoxyphenyl)ethyl>pyrrole-2,5-biscarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of E,Z-3,4-bis(3,4,5-trimethoxyphenyl)-1-<2-(4-methoxyphenyl)ethyl>pyrrole-2,5-biscarboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of E,Z-3,4-bis(3,4,5-trimethoxyphenyl)-1-<2-(4-methoxyphenyl)ethyl>pyrrole-2,5-biscarboxamide

There total 12 articles about E,Z-3,4-bis(3,4,5-trimethoxyphenyl)-1-<2-(4-methoxyphenyl)ethyl>pyrrole-2,5-biscarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-[2-(4-methoxy-phenyl)-ethyl]-3,4-bis-(3,4,5-trimethoxy-phenyl)-1H-pyrrole-2,5-dicarboxylic acid bis-{[2-benzenesulfinyl-2-(4-methoxy-phenyl)-ethyl]-amide}

: 220231-11-8
Z,Z-3,4-bis(3,4,5-trimethoxyphenyl)-1-<2-(4-methoxyphenyl)ethyl>pyrrole-2,5-biscarboxamide

: 220231-09-4
E,Z-3,4-bis(3,4,5-trimethoxyphenyl)-1-<2-(4-methoxyphenyl)ethyl>pyrrole-2,5-biscarboxamide

: (E,E)-storniamide A nonamethyl ether

Guidance literature:: With sodium carbonate; In toluene; at 80 - 110 ℃; for 30h; Yields of byproduct given;
DOI:10.1021/ja982078+

Reference yield:

: 219783-09-2
3,4-bis(3,4,5-trimethoxyphenyl)-1-<2-(4-methoxyphenyl)ethyl>pyrrole-2,5-dicarboxylic acid

: 220231-09-4
E,Z-3,4-bis(3,4,5-trimethoxyphenyl)-1-<2-(4-methoxyphenyl)ethyl>pyrrole-2,5-biscarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / i-Pr₂NEt, PyBrOP / 2 h / 25 °C

2: aq. NaIO₄ / methanol / 6 h / 25 °C

3: Na₂CO₃ / toluene / 30 h / 80 - 110 °C

With sodium periodate; sodium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol; toluene;
DOI:10.1021/ja982078+

Reference yield:

: 53560-33-1
3,4,5-trimethoxyphenylacetylene

: 220231-09-4
E,Z-3,4-bis(3,4,5-trimethoxyphenyl)-1-<2-(4-methoxyphenyl)ethyl>pyrrole-2,5-biscarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / PdCl₂(PPh₃)2, CuI, Bu₄NI, Et₃N / dimethylformamide / 0.5 h / 70 °C

2: 90 percent / toluene / 48 h / 110 °C

3: 69 percent / Zn, AcOH / 18 h / 25 °C

4: 100 percent / K₂CO₃ / dimethylformamide / 1.5 h / 110 °C

5: 100 percent / aq. KOH / methanol; dioxane / 72 h / 70 °C

6: 100 percent / i-Pr₂NEt, PyBrOP / 2 h / 25 °C

7: aq. NaIO₄ / methanol / 6 h / 25 °C

8: Na₂CO₃ / toluene / 30 h / 80 - 110 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; sodium periodate; copper(l) iodide; tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; zinc; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja982078+